Chemical constituents from the roots of (Apocynaceae) and their anti-proliferative activities.

Phytochemical investigation of the roots of Baill. (Apocynaceae) led to the isolation of eleven known compounds. The isolated compounds were identified by analysis of physical and spectroscopic data. We report three phenolic compounds (-), four triterpenoids (-), one coumarin (), one lignan (), one pregnane terpenoid (), and one diterpenoid (). It is the first time that is investigated, and this is therefore the first study of the genus. In addition, compound and are reported from the Apocynaceae family for the first time. Compounds , , and were evaluated against several cancer cell lines (KKU-M213B, KKU-100, KKU-M055, and A549) and cells. Compound showed strong anti-proliferative activity against all the selected cell lines, with IC values in the range of 1.70-6.8 µg/mL.