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Development and Comparative Evaluation of a Reinstructed GPT-4o Model Specialized in Periodontology.
J Clin Periodontol
December 2024
Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
Background: Artificial intelligence (AI) has the potential to enhance healthcare practices, including periodontology, by improving diagnostics, treatment planning and patient care. This study introduces 'PerioGPT', a specialized AI model designed to provide up-to-date periodontal knowledge using GPT-4o and a novel retrieval-augmented generation (RAG) system.
Methods: PerioGPT was evaluated in two phases.
Prognostic significance and therapeutic potential of guanosine triphosphate cyclohydrolase 1 in esophageal squamous cell carcinoma: clinical implications of ferroptosis and lipid peroxidation regulation.
Front Oncol
December 2024
Department of Human Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
Background: Esophageal cancer, particularly esophageal squamous cell carcinoma (ESCC), is a leading cause of cancer-related death and has a poor prognosis. Despite the advancements in multidisciplinary therapies, resistance to conventional treatments warrants the development of novel therapeutic strategies. Ferroptosis, a form of cell death dependent on intracellular iron, has emerged as a potential mechanism for targeting cancer cells resistant to apoptosis.
View Article and Find Full Text PDFAnti-diabetic therapies on dental implant success in diabetes mellitus: a comprehensive review.
Front Pharmacol
December 2024
Faculty of General Medicine, Yaroslavl State Medical University, Yaroslavl, Russia.
Background And Objective: Dental implant therapy faces challenges in patients with Type 1 and Type 2 Diabetes Mellitus (T1DM and T2DM) due to adverse effects on bone metabolism and immune response. Despite advancements, diabetic patients face higher risks of peri-implantitis and compromised osseointegration. This review assesses the impact of anti-diabetic medications on implant outcomes, offering insights to bridge the gap between animal studies and clinical practice.
View Article and Find Full Text PDFEvaluation of the shear bond strength of surface-treated Cobalt-Chromium metal crowns on corticobasal® implant abutments cemented using different luting agents.
J Stomatol Oral Maxillofac Surg
December 2024
Reader, Department of Periodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai 600077, Tamil Nadu, India.. Electronic address:
Purpose: This in-vitro study aimed to compare the shear bond strength (SBS) of cobalt-chromium (Co-Cr) crowns on Corticobasal® implant abutments, evaluating the effects of two surface treatments and two luting agents.
Materials And Methods: Thirty Co-Cr crowns were fabricated using CAD-CAM technology with a direct metal laser sintering process and divided into three groups based on surface treatment: Group I (untreated), Group II (sandblasted with 50 μm Al₂O₃), and Group III (Er: YAG laser etching). Each group was further subdivided based on luting cement: Sub group A (GC Fuji Plus) and Sub group B (Rely X U200).
Osteogenic Induction Activity of Magnesium Chloride on Human Periodontal Ligament Stem Cells.
Int Dent J
December 2024
Center of Excellence for Dental Stem Cell Biology, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand; Department of Anatomy, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand. Electronic address:
Objectives: Periodontal ligament stem cells (PDLSCs) are promising for regenerative therapies due to their self-renewal and multilineage differentiation, essential for periodontal tissue repair. Although magnesium plays a vital role in bone metabolism, its specific effects on PDLSCs and potential applications in regeneration are unclear. This study aimed to investigate the effects of magnesium chloride (MgCl₂) on the proliferation and osteogenic differentiation of human PDLSCs (hPDLSCs).
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