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THE PROTECTIVE ROLE OF ESTRADIOL & PROGESTERONE IN MALE RATS, FOLLOWING GASTRIC ISCHEMIA-REPERFUSION.
Acta Endocrinol (Buchar)
January 2018
Mashhad University of Medical Sciences, Mashhad, Iran.
Background And Aim: Ischemia-reperfusion (I/R) injury frequently occurs in different situations. Female sex hormones have a protective function. The purpose of this study was to determine the function of female sexual hormones on the gastric damage induced by I/R in male rats.
View Article and Find Full Text PDFUrinary cysteinyl progestogens: Occurrence and origin.
J Steroid Biochem Mol Biol
August 2015
Bioanalysis Research Group, IMIM, Hospital del Mar, Doctor Aiguader 88, 08003 Barcelona, Spain. Electronic address:
The presence of two cysteinyl progestogens, 16-cysteinyl-progesterone (16-Cys-Prog) and 16-cysteinyl-pregnenolone (16-Cys-Preg), in human urine is described for the first time. Their occurrence was unequivocally confirmed by comparison with synthesized material by using mass spectrometric detectors. Several experiments were performed in order to clarify their origin.
View Article and Find Full Text PDFEffect of postnatal progesterone therapy following preterm birth on neurosteroid concentrations and cerebellar myelination in guinea pigs.
J Dev Orig Health Dis
August 2015
1Mothers and Babies Research Centre, Hunter Medical Research Institute,Newcastle,NSW,Australia.
Allopregnanolone protects the fetal brain and promotes normal development including myelination. Preterm birth results in the early separation of the infant from the placenta and consequently a decline in blood and brain allopregnanolone concentrations. Progesterone therapy may increase allopregnanolone and lead to improved oligodendrocyte maturation.
View Article and Find Full Text PDFCombination treatment with progesterone and rehabilitation training further promotes behavioral recovery after acute ischemic stroke in mice.
Restor Neurol Neurosci
February 2014
School of Life Sciences, Lanzhou University, China.
Purpose: The present study was aimed to investigate whether combination treatment with progesterone and rehabilitation training would be more effective than monotherapy after cerebral ischemia.
Methods: C57BL/6 mice were subjected to focal ischemia by photothrombosis and were treated with progesterone (2 mg/kg), rehabilitation training or their combination. 2,3,5-triphenyltetrazolium chloride (TTC) staining and Nissl staining were used to measure infarct size at day 3 and day 7 after surgery, and rotarod test and grip strength test were conducted to evaluate behavioral outcomes.
Progesterone attenuates early brain injury after subarachnoid hemorrhage in rats.
Neurosci Lett
May 2013
Department of Neurosurgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, NO. 88 Jiefang road, Hangzhou 310009, China.
Background And Purpose: Although the neuroprotective effects of progesterone against early brain injury (EBI) after trauma have been demonstrated in several studies, whether progesterone reduces EBI after subarachnoid hemorrhage (SAH) remains unknown. In this study, we explored the effect of progesterone on cell apoptosis, stability of the blood-brain barrier (BBB), brain edema, and mortality in male Sprague-Dawley rats subjected to subarachnoid hemorrhage-induced EBI by endovascular perforation.
Method: Rats (n=66) were randomly assigned to sham, SAH+vehicle, and SAH+progesterone groups.
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