Mass spectrometry-based proteomic applications in dental implants research.

Proteomics Clin Appl

Department of Oral- and Craniomaxillofacial Surgery/Translational Implantology, Division of Regenerative Oral Medicine, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.

Published: May 2024

AI Article Synopsis

  • * This review discusses how mass spectrometry (MS)-based proteomics is being used in dental implant research to understand the biology of peri-implant tissues and differentiate between healthy and diseased implants.
  • * The review also covers technical details and suggests improvements for future research studies based on existing findings.

Article Abstract

Dental implants have been established as successful treatment options for missing teeth with steadily increasing demands. Today, the primary areas of research in dental implantology revolve around osseointegration, soft and hard tissue grafting as well as peri-implantitis diagnostics, prevention, and treatment. This review provides a comprehensive overview of the current literature on the application of MS-based proteomics in dental implant research, highlights how explorative proteomics provided insights into the biology of peri-implant soft and hard tissues and how proteomics facilitated the stratification between healthy and diseased implants, enabling the identification of potential new diagnostic markers. Additionally, this review illuminates technical aspects, and provides recommendations for future study designs based on the current evidence.

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Source
http://dx.doi.org/10.1002/prca.202300019DOI Listing

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