AI Article Synopsis
- Smart carrier-based immobilization enhances the application of enzymes in treating various diseases through improved targeted and controlled release.
- Innovative nanocarriers, like polymeric carriers, liposomes, and silica, contribute to better stability, half-life, and absorption of these therapeutic enzymes.
- The review focuses on recent progress in using microbial enzymes as precision nanomedicine against conditions like cancer, thrombosis, PKU, and wound healing, while also addressing challenges for clinical implementation.
Article Abstract
Smart carrier-based immobilization has widened the use of enzymes for the treatment of several disorders. Large surface areas, tunable morphology, and surface modification ability aid the targeted and controlled release of therapeutic enzymes from such formulations. Smart nanocarriers, such as polymeric carriers, liposomes, and silica have also increased the stability, half-life, and permeability of these enzymes. In this review, summarize recent advances in the smart immobilization of microbial enzymes and their development as precision nanomedicine for the treatment of cancer, thrombosis, phenylketonuria (PKU), and wound healing. We also discuss the challenges and measures to be adopted for the successful clinical translation of these formulations.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.drudis.2024.103915 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!