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Understanding the Molecular Mechanisms of Pyrene in Governing the Critical Metabolic Circuits of .
Environ Sci Technol
January 2025
Key Laboratory of Eutrophication and Red Tide Prevention of Guangdong Higher Education Institutes, College of Life Science and Technology, Jinan University, Guangzhou 510632, China.
Pyrene, a representative polycyclic aromatic hydrocarbon, frequently occurs in aquatic environments and is associated with lethal impacts on humans and wildlife. This study examined the impact of pyrene on , a dinoflagellate responsible for harmful algal blooms, and their capability to bioremove pyrene. In a 96 h exposure experiment, effectively reduced the pyrene concentration in seawater to 50, 100, and 200 μg/L, with a combined removal efficiency of 96% in seawater.
View Article and Find Full Text PDFAssociation of early-onset diabetes with socioeconomic, and health factors: a matched case-control study controlling for age, gender, and BMI.
J Diabetes Metab Disord
June 2025
Sports Science Research Center, Kyung Hee University (Global Campus), 1732 Deokyoungdaero, Giheung-gu, Yongin-si, Gyeonggi-do 17014 Republic of Korea.
Objectives: This study examines the link between early-onset diabetes and health factors in South Korean young adults (20-39) using data from the Korea National Health and Nutrition Examination Survey (2010-2020).
Methods: A matched case-control study was conducted in 2022 with 103 patients with diabetes and 103 controls, matched by age, gender, and BMI. All data, including socioeconomic status (income, education, occupation), health behaviors (smoking, alcohol consumption, physical activity), and medical histories, were extracted from the KNHANES database.
Article Synopsis
- The World Health Assembly set six global nutrition targets (GNTs) in 2012 to improve maternal and child health, but there has been no comprehensive report detailing progress from 2012 to 2021.
- A study evaluated the prevalence and impact of these nutrition targets across 204 countries using data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 and projected future trends up to 2050.
- By 2021, only a few countries met some GNTs; most showed increased child overweight and notable decreases in female anaemia, highlighting a connection between societal development status and nutritional challenges.
Characterization of a Putative Lysin from Enterococcus faecalis Phage IME-EFm1 and Determination of its Protective Efficacy in Mice.
Curr Microbiol
December 2024
Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei, 230000, Anhui, China.
The rising tide of bacterial drug resistance has sparked renewed interest in bacteriophages, the natural predators of bacteria. Our study highlights IME-EFm1, a Caudoviricetes bacteriophage specifically targeting Enterococcus faecium. Through our investigations, we identified that the gene IME-EFm1-ORF24 encodes an amidase, referred to as gp24, with promising lytic capabilities.
View Article and Find Full Text PDFMulti-Algorithm-Integrated Tertiary Lymphoid Structure Gene Signature for Immune Landscape Characterization and Prognosis in Colorectal Cancer Patients.
Biomedicines
November 2024
Department of General Surgery, The First Medical Center, Chinese PLA General Hospital, Beijing 100853, China.
Purpose: Colorectal cancer (CRC) is a common malignancy with a low survival rate as well as a low response rate to immunotherapy. This study aims to develop a risk model based on tertiary lymphoid structure (TLS)-associated gene signatures to enhance predictions of prognosis and immunotherapy response.
Methods: TLS-associated gene data were obtained from TCGA-CRC and GEO cohorts.
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