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Human OX40L-CAR-T target activated antigen-presenting cells and control T cell alloreactivity.
Sci Transl Med
October 2024
Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA.
Article Synopsis
- Regulatory T cells (T) help maintain immune balance, but their dysfunction can cause diseases like autoimmunity and rejection of transplanted organs, spurring interest in T cell therapies.
- The study introduces a new type of CAR-T cell that specifically targets OX40 ligand (OX40L), controlled by a synthetic promoter to enhance effectiveness and stability in treating these conditions.
- The engineered OX40L-CAR-T cells showed improved activation, suppressing unwanted immune responses more effectively than standard T cells, and demonstrated potential for controlling both graft-versus-host disease and other autoimmune disorders.
Correction to: OX40 in the Pathogenesis of Atopic Dermatitis-A New Therapeutic Target.
Am J Clin Dermatol
May 2024
Department of Dermatology and the Immunology Institute, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, Box 1047, New York, NY, 10029-6574, USA.
Caecum OX40+CD4 T-cell subset associates with mucosal damage and key markers of disease in treated HIV-infection.
J Microbiol Immunol Infect
December 2023
Institute of Biomedicine of Seville, IBiS, Virgen del Rocío University Hospital/CSIC/University of Seville, Seville 41013, Spain; Universidad Loyola Andalucía, Facultad de Ciencias de la Salud, Campus Sevilla, 41704, Dos Hermanas, Sevilla, Spain. Electronic address:
Background: Blood OX40-expressing CD4 T-cells from antiretroviral (ART)-treated people living with HIV (PWH) were found to be enriched for clonally-expanded HIV sequences, hence contributing to the HIV reservoir. OX40-OX40L is also a checkpoint regulator of inflammation in multiple diseases. We explored gut mucosal OX40+CD4+ T-cells and their potential significance in HIV disease.
View Article and Find Full Text PDFTNFSF4 is a risk factor for rheumatoid arthritis but not for primary Sjögren's syndrome in the Mexican population.
Immunobiology
July 2022
Unidad de Investigación, Hospital Juárez de México, 07760, Mexico City, Mexico. Electronic address:
Purpose: Rheumatoid arthritis (RA) and primary Sjögren's syndrome (pSS) are autoimmune diseases (ADs) characterized by joint damage and involvement of the salivary glands, respectively. ADs share some susceptibility loci, such as TNFSF4, which is a classical susceptibility gene associated with systemic lupus erythematosus, but its role in RA and pSS is not yet clear. Thus, the aim of this study was to determine whether three TNFSFS4 polymorphisms are associated with RA and pSS.
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