Objectives: Successful orthognathic surgery requires accurate transfer of the intraoperative surgical plan. This study aimed to (1) evaluate the surgical error of a novel intermediate splint in positioning the maxilla during maxilla-first orthognathic surgery and (2) determine factors influencing surgical error.
Materials And Methods: This prospective study examined 83 patients who consecutively underwent Le Fort I osteotomy for correction of skeletal class III deformity using a novel intermediate splint and a bilateral sagittal split osteotomy. Surgical error was the outcome variable, measured as the difference in postoperative translational and rotational maxillary position from the virtual plan. Measures included asymmetry, need and amount for mandibular opening during fabrication of intermediate splints, and planned and achieved skeletal movement.
Results: Mean errors in translation for vertical, sagittal, and transversal dimensions were 1.0 ± 0.7 mm, 1.0 ± 0.6 mm, and 0.7 ± 0.6 mm, respectively; degrees in rotation for yaw, roll, and pitch were 0.8 ± 0.6, 0.6 ± 0.4, and 1.6 ± 1.1, respectively. The transverse error was smaller than sagittal and vertical errors; error for pitch was larger than roll and yaw (both p < 0.001). Error for sagittal, transverse, and roll positioning was affected by the achieved skeletal movement (roll, p < 0.05; pitch and yaw, p < 0.001). Surgical error of pitch positioning was affected by planned and achieved skeletal movement (both p < 0.001).
Conclusions: Using the novel intermediate splint when performing Le Fort I osteotomy allowed for accurate positioning of the maxilla.
Clinical Relevance: The novel intermediate splint for maxillary positioning can be reliably used in clinical routines.
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http://dx.doi.org/10.1007/s00784-024-05526-4 | DOI Listing |
J Dig Dis
December 2024
Department of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong Province, China.
Objectives: We aimed to evaluate the effectiveness and safety of clinical decision support tool (CDST)-guided initial selective intensive induction therapy (IIT) for patients with Crohn's disease (CD) who were treated with ustekinumab (UST) and to identify those most likely to benefit from IIT.
Methods: Patients with active CD were included in this multicenter retrospective study and were categorized as low-, intermediate-, and high-probability responders according to the UST-CDST. IIT was defined as intensive induction by two or three initial doses of weight-based intravenous UST administration.
J Hazard Mater
December 2024
Yangtze Delta Region Institute (Huzhou), University of Electronic Science and Technology of China, Huzhou 313000, China; School of Resources and Environment, University of Electronic Science and Technology of China, Chengdu 611731, China. Electronic address:
Photocatalytic technology provides a new approach for the harmless treatment of low concentration NO in the atmosphere. The development of high-performance semiconductor materials to improve the light absorption efficiency and the separation efficiency of photogenerated carriers is the focus of the research. Bismuth oxybismuth sulfate (BiOSO) shows significant potential for photocatalytic NO purification due to its unique electronic and layered structure.
View Article and Find Full Text PDFChemosphere
December 2024
Laboratory of Environmental Technology, INET, Tsinghua University, Beijing 100084, PR China.
The selective oxidation of NH-N into dinitrogen (N) is still a challenge. Currently, traditional advanced oxidation processes often involve in the chlorine free radicals to increase the selectivity of NH-N oxidation products towards N but is usually accompanied by the production of many toxic disinfection by-product. Herein, we reported a novel catalytic ozonation system (UV/O/MgO/NaSO) for selective NH-N oxidation based on the reducing capability and photochemical properties of NaSO.
View Article and Find Full Text PDFSmall Methods
December 2024
Frumkin Institute of Physical Chemistry and Electrochemistry Russian Academy of Sciences, Leninsky pr., 31, building 4, Moscow, 119071, Russia.
A novel phthalocyanine-based hybrid nanofilm is for the first time successfully applied as an oxidative platform for surface enhanced Raman spectroscopy (SERS) sensing to fine-resolve Raman-inactive compounds. The hybrid is formed by self-assembly of zinc(II) 2,3,9,10,16,17,23,24-Octa[(3',5'-dicarboxy)-phenoxy]phthalocyaninate (ZnPc*) with the solid-supported monolayer of graphene oxide (GO) mediated by zinc acetate metal cluster. Atomic force microscopy, UV-vis and fluorescence spectroscopies confirm that this simple coordination motive in combination with molecular structure of ZnPc* prevents contact quenching of the light-excited triplet state through aromatic stacking with GO particles.
View Article and Find Full Text PDFLung Cancer
December 2024
Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden; Medical Unit Head & Neck, Lung and Skin Cancer, Theme Cancer, Karolinska University Hospital and Comprehensive Cancer Center, Stockholm, Sweden; Thoracic Oncology Center, Theme Cancer, Karolinska University Hospital and Comprehensive Cancer Center, Stockholm, Sweden.
Introduction: Several prognostic scores were developed for non-small-cell lung cancer (NSCLC) patients with brain metastases (BM), though limited data reported for the KRAS-mutated subgroup. KRAS-targeted therapies have improved extracranial and intracranial response, highlighting the need for reliable prognostic biomarkers.
Methods: A retrospective cohort (2010-2020) comprising 220 patients with BM KRAS-mutated NSCLC from two large academic Thoracic Oncology centers (Karolinska and Heidelberg) was analyzed.
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