The present study examines the relationship between circular RNA (circRNA) derived from three genes of the family a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTSs): , and and the host gene expression in non-small-cell lung cancer (NSCLC) with regard to various clinical factors. Notably, an association was identified between expression and specific circRNA molecules, as well as certain expression patterns of and its derived circRNA that were specific to histopathological subtypes. The survival analysis demonstrated that a lower expression in squamous cell carcinoma was associated with extended survival. Furthermore, the higher expression was linked to prolonged survival, while the overexpression of was correlated with a shorter survival. These findings suggest that circRNA molecules may serve as potential diagnostic or prognostic biomarkers for NSCLC, highlighting the importance of considering molecular patterns in distinct cancer subtypes.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10855670 | PMC |
| http://dx.doi.org/10.3390/ijms25031897 | DOI Listing |
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