Background: This study investigated whether patient-specific condylar positioning devices (CPDs) are beneficial compared to the conventional manual positioning of the condyles.
Methods: In this prospective, randomized trial, patients undergoing orthognathic surgery with a bilateral sagittal split osteotomy of the mandible were included. The ascending ramus was positioned with computer-aided designed and computer-aided manufactured (CAD/CAM) patient-specific devices in the CPD group and manually in the control group. Postoperatively, cone-beam computed tomography (CBCT) was performed to align the virtually planned position with the postoperative result.
Results: Thirty patients were enrolled in the study, with 14 randomized to the CPD group and 16 to the control group. In the CPD group, the ascending ramus differed in the postoperative CBCT scan from the virtually planned position by 0.8 mm in the left/right, 0.8 mm in the front/back, and 1.3 mm in the cranial/caudal direction. The corresponding control-group values were 1.1 mm, 1.3 mm, and 1.6 mm. CPD and controls differed significantly for the left/right movement of the rami ( = 0.04) but not for the other directions or rotations ( > 0.05).
Conclusions: The results demonstrate that both methods are accurate, and postoperative results matched the virtually planned position precisely. It can be assumed that the described CPDs are beneficial when a condylar position different from the preoperative is desired.
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http://dx.doi.org/10.3390/jcm13030737 | DOI Listing |
Transfus Med
December 2024
Department of Transfusion Medicine, All India Institute of Medical Sciences, Bhubaneswar, Bhubaneswar, India.
Introduction: The quality of packed red blood cells (PRBC) is influenced by various factors such as the collection and processing method, storage conditions, type of bag materials used, anticoagulant properties, and donor characteristics. Studies have indicated that haemolysis in stored RBC bags is linked to male sex, older age, high haemoglobin count, and increased body mass index (BMI). The study's primary objective was to investigate whether a high BMI, as per Asian Pacific criteria among donors, is associated with an elevated haemolysis rate in stored RBC.
View Article and Find Full Text PDFLong time series of velocity profiles collected by up-looking acoustic profilers in the westernmost sill of the Strait of Gibraltar show an unexpected pattern in the deepest ∼80 m of the water column, consisting in an appreciable diurnal weakening of the measured horizontal velocity. A harmonic analysis performed on long time series reveals a surprising magnitude of S constituent (exactly 1 cpd of frequency) in the horizontal velocity and echo amplitude, which prevails over the rest of diurnal constituents within this depth range, including K, despite being around 200 times smaller than it in the tide generating potential. High resolution echograms collected by a new instrument recently installed in the mooring line, point at the diel vertical migration of living acoustic scatterers (zooplankton) as the most reasonable cause.
View Article and Find Full Text PDFEur J Med Chem
December 2024
Ph.D. Program in Drug Discovery and Development Industry, College of Pharmacy, Taipei Medical University, Taipei, Taiwan; School of Pharmacy, Taipei Medical University, Taipei, Taiwan. Electronic address:
Protein disulfide isomerase (PDI) regulates multiple protein functions by catalyzing the oxidation, reduction, and isomerization of disulfide bonds. The enzyme is considered a potential target for treating thrombosis. We previously developed a potent PDI inhibitor, CPD, which contains the propiolamide as a warhead targeting cysteine residue in PDI.
View Article and Find Full Text PDFJACC Clin Electrophysiol
November 2024
Arrhythmia and Robotic EP Unit, Cardiology Department, Hospital Universitario La Paz, IdiPAZ, Madrid, Spain. Electronic address:
Background: The optimal radiofrequency application (RFa) parameters for safe and durable pulmonary vein isolation (PVI) are debated. High-power short-duration (HPSD) has been used as an alternative to conventional power delivery (CPD).
Objectives: This study sought to compare HPSD 70 W/9-10 s (HPSD-70) with CPD 25-40 W in patients undergoing PVI.
AIDS Res Ther
December 2024
Faculty of Medicine, Division of Population Health and Applied Health Sciences, Faculty of Medicine, Division of Continuing Professional Development, Memorial University of Newfoundland, University of British Columbia, Vancouver, Canada.
Introduction: Many persons are unaware of HIV infection until they present in an advanced stage of the disease. Diagnosing HIV infection in its earliest stages reduces morbidity and mortality and contributes to improved public health. Increased testing for HIV is critical for prevention, and primary care providers play an essential role in early HIV screening.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!