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Risk factors and drug resistance of adult community-onset urinary tract infections caused by producing extended-spectrum β-lactamase in the Chongqing region, China: a retrospective case-control study.
BMJ Open
October 2024
Department of Infectious Disease, The People's Hospital of Dazu Chongqing, Chongqing, China.
Article Synopsis
- The study aimed to investigate the occurrence, resistance, and risk factors related to community-onset urinary tract infections (COUTIs) caused by bacteria that produce extended-spectrum β-lactamases (ESBL-EC).
- Conducted at a major hospital in China, this retrospective case-control analysis focused on adult patients with community-acquired UTIs, examining cases from May 2017 to December 2022 and excluding those with incomplete data or prior hospitalizations.
- Results indicated that nearly 49% of COUTIs were due to ESBL-EC, with several significant risk factors identified, including previous urolithiasis procedures, urological surgery, recent hospitalizations, presence of an indwelling catheter, and previous
spp. in Domestic Ruminants, Evaluation of Antimicrobial Resistance Based on the One Health Approach-A Systematic Review and Meta-Analysis.
Vet Sci
July 2024
Social Psychology and Methodology Department, Universidad Autónoma de Madrid, Ciudad Universitaria de Cantoblanco, 28049 Madrid, Spain.
spp. pose a global threat as a leading cause of foodborne illnesses, particularly prevalent in the European Union (EU), where it remains the second cause of foodborne outbreaks. The emergence of antimicrobial resistance (AMR) in spp.
View Article and Find Full Text PDFUreidopenicillins Are Potent Inhibitors of Penicillin-Binding Protein 2 from Multidrug-Resistant H041.
ACS Infect Dis
April 2024
Department of Biochemistry and Molecular Biology, University of South Alabama, Mobile, Alabama 36688, United States.
Effective treatment of gonorrhea is threatened by the increasing prevalence of strains resistant to the extended-spectrum cephalosporins (ESCs). Recently, we demonstrated the promise of the third-generation cephalosporin cefoperazone as an antigonococcal agent due to its rapid second-order rate of acylation against penicillin-binding protein 2 (PBP2) from the ESC-resistant strain H041 and robust antimicrobial activity against H041. Noting the presence of a ureido moiety in cefoperazone, we evaluated a subset of structurally similar ureido β-lactams, including piperacillin, azlocillin, and mezlocillin, for activity against PBP2 from H041 using biochemical and structural analyses.
View Article and Find Full Text PDFMolecular Characterisation of Antimicrobial Resistance in Isolates from Piglets in the West Region of Romania.
Antibiotics (Basel)
October 2023
Horia Cernescu Research Unit, Faculty of Veterinary Medicine, University of Life Sciences King Michael I, Calea Aradului 119, 300645 Timisoara, Romania.
Antibiotics are widely used for prophylaxis and therapy, reducing morbidity and mortality produced by bacterial pathogensin pigs, including infections caused by . The aim of this study was to characterise antibiotic resistance phenotypes and genotypes in isolates in pigs in West Romanian grower farms. Differential phenotypic susceptibility profiles and the contribution of resistance genes to phenotypic expression of susceptibility or resistance were evaluated.
View Article and Find Full Text PDFRisk-factor analysis and predictive-model development of acute kidney injury in inpatients administered cefoperazone-sulbactam sodium and mezlocillin-sulbactam sodium: a single-center retrospective study.
Front Pharmacol
June 2023
Department of Clinical Pharmacy, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Shandong Engineering and Technology Research Center for Pediatric Drug Development, Shandong Medicine and Health Key Laboratory of Clinical Pharmacy, Jinan, China.
Acute kidney injury (AKI) is a common adverse reaction observed with the clinical use of cefoperazone-sulbactam sodium and mezlocillin-sulbactam sodium. Based upon real-world data, we will herein determine the risk factors associated with AKI in inpatients after receipt of these antimicrobial drugs, and we will develop predictive models to assess the risk of AKI. Data from all adult inpatients who used cefoperazone-sulbactam sodium and mezlocillin-sulbactam sodium at the First Affiliated Hospital of Shandong First Medical University between January 2018 and December 2020 were analyzed retrospectively.
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