AI Article Synopsis
- A synthesis method has been developed for -acyl anthranilic acids using silver as a catalyst to create imino-ketenes from anthranils and carboxylic acids.
- This process works well with various carboxylic acids, including bulky aliphatic, aromatic, and amino acids.
- It can also be applied to enhance drug molecules and natural products, like ibuprofen and acetylglycine.
Article Abstract
A practical synthesis of valuable -acyl anthranilic acids has been achieved via a silver-catalyzed imino-ketene generation from readily available anthranils and carboxylic acids. A wide range of carboxylic acids including sterically demanding aliphatic carboxylic acids, aromatic carboxylic acids, acrylic acids, and amino acids are compatible in this reaction. Moreover, this method can be used to modify drug molecules and natural products, such as ibuprofen, probenecid, and acetylglycine.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.joc.3c02586 | DOI Listing |
Publication Analysis
Top Keywords
carboxylic acids
20
acids
9
practical synthesis
8
-acyl anthranilic
8
anthranilic acids
8
anthranils carboxylic
8
carboxylic
5
ag-catalyzed practical
4
synthesis -acyl
4
acids anthranils
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!