AI Article Synopsis
- * Current methods for studying these processes are limited, but the authors used statistical mechanics, computer modeling, and chemical kinetics to analyze how fibrils behave when a specific inhibitor is present or absent.
- * They discovered that small catalytic sites on the surface of Aβ amyloid fibrils are responsible for self-replication, and these sites are sufficiently spaced that a single inhibitor can cover each one, helping to control the aggregation process.
Article Abstract
Self-replication of amyloid fibrils via secondary nucleation is an intriguing physicochemical phenomenon in which existing fibrils catalyze the formation of their own copies. The molecular events behind this fibril surface-mediated process remain largely inaccessible to current structural and imaging techniques. Using statistical mechanics, computer modeling, and chemical kinetics, we show that the catalytic structure of the fibril surface can be inferred from the aggregation behavior in the presence and absence of a fibril-binding inhibitor. We apply our approach to the case of Alzheimer's A[Formula: see text] amyloid fibrils formed in the presence of proSP-C Brichos inhibitors. We find that self-replication of A[Formula: see text] fibrils occurs on small catalytic sites on the fibril surface, which are far apart from each other, and each of which can be covered by a single Brichos inhibitor.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10873593 | PMC |
| http://dx.doi.org/10.1073/pnas.2220075121 | DOI Listing |
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