AI Article Synopsis
- Three diterpenoids were isolated from the fruits of Vitex rotundifolia and their structures were analyzed using spectroscopic techniques.
- In experiments with RAW264.7 cells stimulated by lipopolysaccharides, the compounds reduced levels of reactive oxygen species and nitric oxide in a dose-dependent manner.
- At a concentration of 25 μM/mL, the compounds also lowered the expression of pro-inflammatory cytokines, with compound 3 showing the strongest inhibitory effect.
Article Abstract
In this study, three diterpenoids (1-3), including one known compound (1), were isolated from the fruits of Vitex rotundifolia and their structures were determined via spectroscopic analysis. In lipopolysaccharide-stimulated RAW264.7 cells, these compounds dose-dependently decreased the intracellular reactive oxygen species levels and nitric oxide production compared to those in the control cells. At 25 μM/mL, these compounds also diminished the protein expression of the pro-inflammatory cytokines, inducible nitric oxide synthase, cyclooxygenase-2, and interleukin-6, with compound 3 exhibiting the most potent inhibitory effect.
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| http://dx.doi.org/10.1002/cbdv.202301115 | DOI Listing |
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