A numerical study was conducted on an axial compressor, the NASA Stage 35, with three nonuniform tip clearances to understand the effect of a different shape tip clearances rotor on the compressor's performance. The results demonstrated that by modifying the traditional parallel tip clearance to sine-type tip clearance (STC), hump-type tip clearance (HTC), and concave-type tip clearance (CTC), the compressor's peak efficiency showed remarkable improvement and the SMI was significantly improved. In comparison to the design rotor, the SMI of STC, HTC, and CTC increased by 3.102 %, 2.672 %, and 0.645 %, respectively. The leakage distribution at the tip-clearance region from LE to TE exhibited an inverse pattern to that of the tip curve. The leakage's magnitude could not reflect the TLF's intensity, and the leakage in the middle of the blade tip had a role in the size of the TLV. Leakage at the tip's TE influenced the corner separation's scale in the casing. The STC and HTC schemes' total pressure ratio improved, the low-velocity zone's area, high-entropy area, and high absolute vorticity area at the LE of rotor's PS decreased, the detached shock moved backward, the leading-edge spillage flow decreased, the shock action position of the rotor suction surface moved forward, the BLS increased, the TPL in the stator channel decreased, and the CTC exhibited the opposite trend. A nonuniform tip clearance was achieved by reducing the leakage and TLV intensity, thereby reducing the size of the TLV, induced vortex, or CSV in rotor passage and increasing the compressor's SMI.
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http://dx.doi.org/10.1016/j.heliyon.2024.e25296 | DOI Listing |
Sci Prog
January 2024
College of Mechanical Engineering, Zhejiang University of Technology, Hangzhou, China.
As the critical components in hydrogen refueling, storage, and transportation systems, the degradation and failure of rubber O-ring seals under a high-pressure (HP) hydrogen environment (up to 100 MPa) directly affect hydrogen energy safety. Clarifying the interaction mechanism of hydrogen diffusion and the mechanical properties of rubber seals is essential for HP hydrogen infrastructure. A hydrogen diffusion-mechanical sequential numerical model is built to investigate the sealing performance and hydrogen diffusion behaviors of rubber seals using ABAQUS software.
View Article and Find Full Text PDFMacromol Biosci
January 2025
Department of materials engineering, Isfahan University of Technology, Isfahan, 84156-83111, Iran.
The stratum corneum, which acts as a strong barrier against external agents, presents a significant challenge to transdermal drug delivery. In this regard, microneedle (MN) patches, designed as modern systems for drug delivery via permeation through the skin with the ability to pass through the stratum corneum, are known to be convenient, painless, and effective. In fact, MN have shown significant breakthroughs in transdermal drug delivery, and among the various types, hydrogel MN (HMNs) have demonstrated desirable inherent properties.
View Article and Find Full Text PDFInsects
August 2024
Laboratory of Applied Entomology and Parasitology, Department of Theoretical and Applied Sciences (DiSTA), University of Insubria, 21100 Varese, Italy.
The aim of this work was to develop an experimental protocol for the infection of with Gram-positive bacteria. Some physiological characteristics of these insects are comparable to those of vertebrates, therefore allowing the replacement of mammals in the preclinical phases of drug development. Linnaeus 1758 (Lepidoptera: Pyralidae) is accepted as an alternative model for the study of infectious diseases.
View Article and Find Full Text PDFCPT Pharmacometrics Syst Pharmacol
September 2024
Simcyp Division, Certara UK Ltd, Sheffield, UK.
OATP1B facilitates the uptake of xenobiotics into hepatocytes and is a prominent target for drug-drug interactions (DDIs). Reduced systemic exposure of OATP1B substrates has been reported following multiple-dose rifampicin; one explanation for this observation is OATP1B induction. Non-uniform hepatic distribution of OATP1B may impact local rifampicin tissue concentrations and rifampicin-mediated protein induction, which may affect the accuracy of transporter- and/or metabolizing enzyme-mediated DDI predictions.
View Article and Find Full Text PDFNat Commun
June 2024
Section of Food Microbiology, Gut Health, and Fermentation, Department of Food Science, University of Copenhagen, Frederiksberg, Denmark.
Metabolic syndrome encompasses amongst other conditions like obesity and type-2 diabetes and is associated with gut microbiome (GM) dysbiosis. Fecal microbiota transplantation (FMT) has been explored to treat metabolic syndrome by restoring the GM; however, concerns on accidentally transferring pathogenic microbes remain. As a safer alternative, fecal virome transplantation (FVT, sterile-filtrated feces) has the advantage over FMT in that mainly bacteriophages are transferred.
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