Auto-brewery syndrome (ABS) is a rare medical condition, wherein gut microbiota ferment carbohydrates to alcohol. Risk factors for ABS include diets high in carbohydrates and sugars, diabetes mellitus, prior gastrointestinal surgery, nonalcoholic fatty liver disease, and certain genetic mutations, among others. We provide a case of ABS that developed after known COVID-19 infection, which may be one of the contributing factors to its development.
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http://dx.doi.org/10.14309/crj.0000000000001248 | DOI Listing |
J Hepatol
December 2024
Microbiology Department, Ramón y Cajal Hospital and Institute Ramón y Cajal de Investigaciones Sanitarias (IRYCIS), Madrid, Spain; CIBER de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain; Faculty of Health Sciences, Alfonso X El Sabio University (UAX), Villanueva de la Cañada, Spain. Electronic address:
NeuroSci
September 2024
Nova Institute for Health, Baltimore, MD 21231, USA;
Nat Rev Gastroenterol Hepatol
August 2024
Department of Medicine, University of California San Diego, La Jolla, CA, USA.
The gut microbiome exerts metabolic actions on distal tissues and organs outside the intestine, partly through microbial metabolites that diffuse into the circulation. The disruption of gut homeostasis results in changes to microbial metabolites, and more than half of the variance in the plasma metabolome can be explained by the gut microbiome. Ethanol is a major microbial metabolite that is produced in the intestine of nearly all individuals; however, elevated ethanol production is associated with pathological conditions such as metabolic dysfunction-associated steatotic liver disease and auto-brewery syndrome, in which the liver's capacity to metabolize ethanol is surpassed.
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