Background: The prevalence of peptic ulcers is increasing due to lifestyle changes and harmful diets.
Objective: The aim of this study was to investigate the effect of fish oil (FO) on gastric ulcers induced by ethanol in rats.
Methods: The pharmacological efficacy of FO with doses of 5 and 10 mg/kg investigated using the gastric ulcer index, the acidity of gastric secretions, pro-inflammatory cytokine assessment, and oxidative stress examination.
Results: Ethanol-induced gastric ulcer improves with FO 5 or 10 mg/kg pretreatment (<0.05). FO did have acid-neutralizing activity. FO also increased the levels of glutathione and catalase and decreased the malondialdehyde levels (<0.05). Moreover, FO reduced the levels of tumour necrosis factor alpha (TNF-α) interleukin-6 (IL-6), through downregulation of nuclear factor kappa B (NF-κB) (<0.05). Pretreatment with FO attenuates ethanol-induced gastric ulceration.
Conclusion: The observed effects may be due to the role of FO in regulating gastric secretions, changes in the expression of NF-κB, and changes in the levels of oxidative stress factors.
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| http://dx.doi.org/10.1097/MS9.0000000000001550 | DOI Listing |
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