AI Article Synopsis
- In Lusaka, Zambia, researchers studied adults with chronic hepatitis B and some with HIV by using a technique called fine needle aspiration (FNA) to take samples from their livers.
- They enrolled over 117 people and safely performed 47 follow-up procedures, making sure the participants were okay with the process.
- By analyzing the samples, they discovered different types of immune cells, which could help them learn more about hepatitis B and how to treat it better in Africa.
Article Abstract
In Lusaka, Zambia, we introduced liver fine-needle aspiration biopsy (FNAB) into a research cohort of adults with treatment-naive chronic hepatitis B virus (HBV) infection, with and without human immunodeficiency virus (HIV) coinfection, as well as with acute HBV infection. From 117 enrollment and 47 longitudinal FNABs (at 1-year follow-up), we established participant acceptability and safety. We also demonstrated the quality of the material through single-cell RNA sequencing of selected enrollment FNAs, which revealed a range of immune cells. This approach can drive new insights into HBV immunology, informing cure strategies, and can improve our understanding of HBV natural history in Africa.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11565906 | PMC |
| http://dx.doi.org/10.1093/infdis/jiae054 | DOI Listing |
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