AI Article Synopsis
- - The study analyzed over 8,400 adults over 40 to see how the sizes of brain arteries correlate with dementia and stroke risk using MRI scans.
- - Findings showed that larger overall and carotid artery diameters significantly increase the risk of dementia (up to 1.74 times) and stroke (up to 2.11 times for basilar arteries).
- - The results suggest that measuring brain artery sizes through MRI could be a valuable tool for predicting dementia and stroke risk across different populations.
Article Abstract
Introduction: We tested the association of brain artery diameters with dementia and stroke risk in three distinct population-based studies using conventional T2-weighted brain magnetic resonance imaging (MRI) images.
Methods: We included 8420 adults > 40 years old from three longitudinal population-based studies with brain MRI scans. We estimated and meta-analyzed the hazard ratios (HRs) of the brain and carotids and basilar diameters associated with dementia and stroke.
Result: Overall and carotid artery diameters > 95th percentile increased the risk for dementia by 1.74 (95% confidence interval [CI], 1.13-2.68) and 1.48 (95% CI, 1.12-1.96) fold, respectively. For stroke, meta-analyses yielded HRs of 1.59 (95% CI, 1.04-2.42) for overall arteries and 2.11 (95% CI, 1.45-3.08) for basilar artery diameters > 95th percentile.
Discussion: Individuals with dilated brain arteries are at higher risk for dementia and stroke, across distinct populations. Our findings underline the potential value of T2-weighted brain MRI-based brain diameter assessment in estimating the risk of dementia and stroke.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11032539 | PMC |
| http://dx.doi.org/10.1002/alz.13712 | DOI Listing |
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