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Efficacy and safety of using auditory-motor entrainment to improve walking after stroke: a multi-site randomized controlled trial of InTandem. | LitMetric

AI Article Synopsis

  • * 87 stroke survivors participated in walking interventions over 5 weeks, measuring changes in walking speed and safety through adverse events.
  • * Results showed that InTandem led to a 2x greater increase in walking speed and a 3x higher rate of clinical responders, while both groups reported similar safety outcomes.

Article Abstract

Walking slowly after stroke reduces health and quality of life. This multi-site, prospective, interventional, 2-arm randomized controlled trial (NCT04121754) evaluated the safety and efficacy of an autonomous neurorehabilitation system (InTandem) designed to use auditory-motor entrainment to improve post-stroke walking. 87 individuals were randomized to 5-week walking interventions with InTandem or Active Control (i.e., walking without InTandem). The primary endpoints were change in walking speed, measured by the 10-meter walk test pre-vs-post each 5-week intervention, and safety, measured as the frequency of adverse events (AEs). Clinical responder rates were also compared. The trial met its primary endpoints. InTandem was associated with a 2x larger increase in speed (Δ: 0.14 ± 0.03 m/s versus Δ: 0.06 ± 0.02 m/s, F(1,49) = 6.58, p = 0.013), 3x more responders (40% versus 13%, χ(1) ≥ 6.47, p = 0.01), and similar safety (both groups experienced the same number of AEs). The auditory-motor intervention autonomously delivered by InTandem is safe and effective in improving walking in the chronic phase of stroke.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10853163PMC
http://dx.doi.org/10.1038/s41467-024-44791-5DOI Listing

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