AI Article Synopsis
- * Cobra venom leads to a decrease in heart muscle's contractile force, while rattlesnake venom increases both the strength and frequency of heart contractions.
- * The findings demonstrate distinct and complex effects of snake venoms on heart function, emphasizing the varying impacts on heart cell structure.
Article Abstract
Here we describe the acute myocardial effects of an elapid (red spitting cobra, Naja pallida) and a viper (western diamondback rattlesnake, Crotalus atrox) venom using an ex vivo heart model. Our results reveal two different pathophysiological trajectories that influence heart function and morphology. While cobra venom causes a drop in contractile force, rattlesnake venom causes enhanced contractility and frequency that coincides with differences in myocellular morphology. This highlights the medical complexity of snake venom-induced cardiotoxicity.
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| http://dx.doi.org/10.1016/j.toxicon.2024.107637 | DOI Listing |
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