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| http://dx.doi.org/10.1001/jama.2023.27932 | DOI Listing |
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Artesunate remarkably alleviates interstitial cystitis/bladder pain syndrome in a murine model: Novel molecular signature deciphered by bulk tissue and single-cell transcriptomic analysis.
FASEB J
December 2024
Department of Urology, Zhejiang Cancer Hospital, Hangzhou, China.
Article Synopsis
- - Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic pain condition with unclear causes, which leads to lower urinary tract issues and has shown inconsistent treatment results due to its complex nature.
- - Researchers created a mouse model of IC/BPS using specific chemicals and tested the effects of artesunate (ART), finding significant symptom relief and histological improvements, alongside identifying key gene modules related to the condition.
- - The study reveals changes in immune cells related to IC/BPS and represents a pioneering approach using single-cell transcriptomics to understand the immune environment, suggesting ART's potential therapeutic role, although further patient-focused studies are necessary.
Trends in Phenylephrine and Pseudoephedrine Sales in the US.
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March 2024
Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada.
Oxytocin infusion for maintenance of uterine tone under prophylactic phenylephrine infusion for prevention of post-spinal hypotension in cesarean delivery: a prospective randomised double-blinded dose-finding study.
BMC Pregnancy Childbirth
December 2023
Department of Anesthesia, Hangzhou Women's Hospital (Hangzhou Maternity and Child Health Care Hospital, Hangzhou First People's Hospital Qianjiang New City Campus, Zhejiang Chinese Medical University), Hangzhou, China.
Background: Prior studies have shown that, when administered as an intravenous bolus to prevent uterine atony, prophylactic phenylephrine infusion increased the dose requirement of oxytocin and second-line uterotonics. For the prevention of uterine atony, oxytocin should be delivered by continuous infusion. Here, we aimed to determine the ED50 and ED90 parameters (the effective doses for 50 and 90% patients without uterine atony) of oxytocin for co-infusion with prophylactic phenylephrine during cesarean delivery.
View Article and Find Full Text PDFThe effect of combining prewarming with intraoperative phenylephrine infusion on the prevention of hypothermia in patients undergoing urological surgery: a prospective, randomized, and controlled trial.
Int J Med Sci
November 2023
Department of Anaesthesiology and Pain Medicine, Konyang University Hospital, Konyang University Myunggok Medical Research Institute, Konyang University College of Medicine, Daejeon, Korea.
Hypothermia is common in patients undergoing urological surgery; however, no single preventative modality is completely effective. This study evaluated the effects of combining prewarming with intraoperative phenylephrine infusion for the prevention of hypothermia in patients undergoing urological surgery. This prospective study enrolled 58 patients scheduled for urological surgery under general anesthesia.
View Article and Find Full Text PDFEvaluation of Electrical Cardiometry for Measuring Cardiac Output and Derived Hemodynamic Variables in Comparison with Lithium Dilution in Anesthetized Dogs.
Animals (Basel)
July 2023
Department of Veterinary Clinical Sciences, The Ohio State University-College of Veterinary Medicine, Columbus, OH 43210, USA.
Numerous cardiac output (CO) technologies were developed to replace the 'gold standard' pulmonary artery thermodilution due to its invasiveness and the risks associated with it. Minimally invasive lithium dilution (LiD) shows excellent agreement with thermodilution and can be used as a reference standard in animals. This study evaluated CO via noninvasive electrical cardiometry (EC) and acquired hemodynamic variables against CO measured using LiD in six healthy, anesthetized dogs administered different treatments (dobutamine, esmolol, phenylephrine, and high-dose isoflurane) impacting CO values.
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