Purpose: Arterial spin labeling (ASL) represents a noninvasive perfusion biomarker, and, in the study of nonvascular disease, the use of the single-timepoint ASL technique is recommended. However, the obtained cerebral blood flow (CBF) maps may be highly influenced by delayed arterial transit time (ATT). Our aim was to assess the complexity of hemodynamic information of single-timepoint CBF maps using a new visual scale and comparing it with an ATT proxy, the "coefficient of spatial variation" (sCoV).
Material And Methods: Individual CBF maps were estimated in a memory clinic population (mild cognitive impairment, dementia and cognitively unimpaired controls) and classified into four levels of delayed perfusion based on a visual rating scale. Calculated measures included global/regional sCoVs and common CBF statistics, as mean, median and standard deviation. One-way ANOVA was performed to compare these measures across the four groups of delayed perfusion. Spearman correlation was used to study the association of global sCoV with clinical data and CBF statistics.
Results: One hundred and forty-four participants (72 ± 7 years, 53% women) were included in the study. The proportion of maps with none, mild, moderate, and severe delayed perfusion was 15, 20, 37, and 28%, respectively. SCoV demonstrated a significant increase (p < 0.05) across the four groups, except when comparing none vs mild delayed perfusion groups (p > 0.05). Global sCoV values, as an ATT proxy, ranged from 67 ± 4% (none) to 121 ± 24% (severe delayed) and were significantly associated with age and CBF statistics (p < 0.05).
Conclusion: The impact of ATT delay in single-time CBF maps requires the use of a visual scale or sCoV in clinical or research settings.
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http://dx.doi.org/10.1007/s11547-024-01777-z | DOI Listing |
Lab Anim
December 2024
Cooperative Division of Veterinary Sciences, Tokyo University of Agriculture and Technology, Tokyo, Japan.
This study aimed to investigate the impact of selected analysis conditions on blood flow values and color maps in canine brain perfusion computed tomography (PCT) and to propose optimal analysis conditions. Dynamic computed tomography imaging was performed on six beagle dogs. Color maps were generated using a combination of analysis algorithms (box-modulation transfer function (Box-MTF) and singular value deconvolution plus (SVD+) methods), slice thicknesses (4.
View Article and Find Full Text PDFRadiol Med
December 2024
DeepClue Inc., Daejeon, Republic of Korea.
Purpose: To investigate the clinical feasibility of a CT collateral map compared with an MRA collateral map, focusing on collateral perfusion (CP) estimation and baseline lesion assessment in acute ischemic stroke (AIS).
Materials And Methods: This retrospective analysis used selected data from a prospectively collected database. We generated CT collateral maps derived from CT perfusion, encompassing images of arterial, capillary, early venous (CMEV), late venous, and delay phases.
Magn Reson Med
December 2024
Wellcome Centre for Integrative Neuroimaging, FMRIB Division, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Purpose: B field inhomogeneity within the brain-feeding arteries is a major issue for pseudo-continuous arterial spin labeling (PCASL) at 7 T because it reduces the labeling efficiency and leads to a loss of perfusion signal. This study aimed to develop a vessel-specific dynamic B field shimming method for 7 T PCASL to improve the labeling efficiency by correcting off-resonance within the arteries in the labeling region.
Methods: We implemented a PCASL sequence with dynamic B shimming at 7 T that compensates for B field offsets in the brain-feeding arteries by updating linear shimming terms and adding a phase increment to the PCASL RF pulses.
J Imaging Inform Med
December 2024
Institute of Medical Device and Imaging, College of Medicine, Zhongzheng Dist, National Taiwan University, No.1, Sec. 1, Jen Ai Rd, Taipei City, 100, Taiwan.
Dynamic computed tomography (CT)-based brain perfusion imaging is a non-invasive technique that can provide quantitative measurements of cerebral blood flow (CBF), cerebral blood volume (CBV), and mean transit time (MTT). However, due to high radiation dose, dynamic CT scan with a low tube voltage and current protocol is commonly used. Because of this reason, the increased noise degrades the quality and reliability of perfusion maps.
View Article and Find Full Text PDFNeuroscience
December 2024
Centre ChronoS, GHU Paris - Psychiatry & Neurosciences, Paris, France; Department of Psychiatry and Addictology, AP-HP, GHU Paris Nord, DMU Neurosciences, Bichat-Claude Bernard Hospital, Paris, France; Université Paris Cité, NeuroDiderot, Inserm, Paris, France.
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