TNF signaling does not result in cell death unless multiple inhibitory signals are overcome, which can be accomplished by simultaneous signaling through IFNγ. In this issue, Deng and colleagues (http://doi.org/10.1083/jcb.202305026) dissect the mechanisms by which IFNγ signaling combines with TNF to mediate cell death through caspase-8, discussed by James E. Vince.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10853068 | PMC |
| http://dx.doi.org/10.1083/jcb.202401127 | DOI Listing |
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