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View Article and Find Full Text PDFMixed germ cell-sex cord stromal tumour of the testis and ovary: comparison and contrast.
Pathology
February 2021
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA; Department of Urology, Indiana University School of Medicine, Indianapolis, IN, USA.
Article Synopsis
- Mixed germ cell-sex cord stromal tumors (MGC-SCSTs) in testes and ovaries show notable differences in their appearance, behavior, and genetics.
- Testicular MGC-SCSTs were previously thought to be histologically bland, but new studies reveal that some may exhibit histological abnormalities and chromosomal changes.
- While all reported testicular cases have been clinically benign, ovarian tumors can potentially lead to aggressive malignancies, indicating a difference in the underlying genetic and epigenetic factors.
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