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Temporal increase in Ki-67 index in patients with pancreatic neuroendocrine tumours.
Endocr Relat Cancer
January 2025
L de Mestier, UMR1149, Centre of Research on Inflammation, Université Paris Cité, Paris, 75018, France.
Pancreatic neuroendocrine tumours (PanNETs) have intra-tumour heterogeneity, notably regarding the Ki-67 index, which is a major prognostic factor. The temporal evolution of PanNET biology is poorly known. We aimed to study the prognostic impact of the temporal evolution of Ki-67 and other molecular markers (MEN1, ATRX/DAXX, PDX1/ARX) in PanNETs.
View Article and Find Full Text PDFIs hypercalcemia immediately life-threatening ? A prospective study.
Endocr Connect
January 2025
C Guimard, Department of Medicine, Clinique Jules Verne, Nantes, France.
Objective: Hypercalcemia is often considered as an emergency because of a potential risk life-threatening arrhythmias or coma. However, there is little evidence, apart from case studies, that hypercalcemia can be immediately life-threatening. The aim of our study was to assess prospectively, if hypercalcemia (Ca ≥ 3 mmol/L) was associated with immediately life-threatening complications.
View Article and Find Full Text PDFEvaluation of the interaction between Menthol and Camphor, Major Compounds of Clinopodium nepeta Essential Oil: Antioxidant, Anti-inflammatory and Anticancer Activities against Breast Cancer Cell Lines.
Chem Biodivers
January 2025
Mohammed I University Oujda: Universite Mohammed Premier Oujda, Biology department, BV Mohammed VI B.P. 524 Oujda, Oujda, 60000, Oujda, MOROCCO.
This study evaluates the antioxidant, anti-inflammatory and anticancer activities of camphor, menthol and their equimolar combination. In silico toxicity analysis confirmed the absence of toxic effects for both compounds. Antioxidant activity, assessed by 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assays, revealed a synergistic effect of the equimolar combination with IC50 values of 10.
View Article and Find Full Text PDFHead and neck automatic multi-organ segmentation on Dual-Energy Computed Tomography.
Phys Imaging Radiat Oncol
October 2024
Université Paris-Saclay, Gustave Roussy, Inserm, Molecular Radiotherapy and Therapeutic Innovation, U1030, 94800 Villejuif, France.
Background And Purpose: Deep-learning-based automatic segmentation is widely used in radiation oncology to delineate organs-at-risk. Dual-energy CT (DECT) allows the reconstruction of enhanced contrast images that could help with manual and auto-delineation. This paper presents a performance evaluation of a commercial auto-segmentation software on image series generated by a DECT.
View Article and Find Full Text PDFThe role of artificial intelligence and image processing in the diagnosis, treatment, and prognosis of liver cancer: a narrative-review.
Prz Gastroenterol
September 2024
Department of Surgery, General University Hospital of Patras, Patras, Greece.
Artificial intelligence (AI) and image processing are revolutionising the diagnosis and management of liver cancer. Recent advancements showcase AI's ability to analyse medical imaging data, like computed tomography scans and magnetic resonance imaging, accurately detecting and classifying liver cancer lesions for early intervention. Predictive models aid prognosis estimation and recurrence pattern identification, facilitating personalised treatment planning.
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