AI Article Synopsis
- - The study investigates the potential of plasma biomarkers to detect Alzheimer's disease (AD) pathology in patients with dementia with Lewy bodies (DLB), focusing on early stages like prodromal and mild cognitive impairment with Lewy bodies (MCI-LB).
- - A cohort of patients underwent blood tests and PET scans, revealing that abnormal levels of certain plasma biomarkers, particularly glial fibrillary acidic protein (GFAP) and phosphorylated tau (p-tau)-181, were associated with amyloid and tau deposition at different disease stages.
- - The findings suggest that plasma p-tau-181 and GFAP are effective in identifying Alzheimer's-related changes in DLB patients, highlighting their potential as valuable diagnostic tools.
Article Abstract
Introduction: Patients with dementia with Lewy bodies (DLB) may have Alzheimers disease (AD) pathology that can be detected by plasma biomarkers. Our objective was to evaluate plasma biomarkers of AD and their association with positron emission tomography (PET) biomarkers of amyloid and tau deposition in the continuum of DLB, starting from prodromal stages of the disease.
Methods: The cohort included patients with isolated rapid eye movement (REM) sleep behavior disorder (iRBD), mild cognitive impairment with Lewy bodies (MCI-LB), or DLB, with a concurrent blood draw and PET scans.
Results: Abnormal levels of plasma glial fibrillary acidic protein (GFAP) were found at the prodromal stage of MCI-LB in association with increased amyloid PET. Abnormal levels of plasma phosphorylated tau (p-tau)-181 and neurofilament light (NfL) were found at the DLB stage. Plasma p-tau-181 showed the highest accuracy in detecting abnormal amyloid and tau PET in patients with DLB.
Discussion: The range of AD co-pathology can be detected with plasma biomarkers in the DLB continuum, particularly with plasma p-tau-181 and GFAP.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11032523 | PMC |
| http://dx.doi.org/10.1002/alz.13653 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!