Introduction: Diabetes mellitus is a metabolic disease that affects millions of people worldwide. The complications caused by this disease in many cases lead to a deterioration of the quality of life of patients. An additional factor that negatively affects the quality of life of respondents is disability, which in many cases is diagnosed due to diabetes.
Objective: The aim of the study was to quantify the impact of disability on the declared quality of life in patients with diabetes and to compare the percentage of people with declared disability with the degree of disability among people with type 1 and type 2 diabetes.
Material And Methods: The study was based on an internet survey posted on social groups related to diabetes on Facebook. The shortened version of the questionnaire measuring quality of life created by the World Health Organization (WHOQOL-Bref) and some self-created questions were used. The survey was completed by 139 respondents. 113 (81.3%) of them were diagnosed with type 1 diabetes mellitus, and 26 (18.7%) with type 2 diabetes mellitus.
Results: The subjective assessment of the quality of life in the entire group was moderate and totalled 3.5 ± 0.9 (on a scale from 1 to 5). The mean score of the physical domain of the WHOQOL-Bref was 48.9 ± 13.1, of the psychological domain was 55.2 ± 13.5, of the social domain was 60.8 ± 22.1, and of the environmental domain was 54.6 ± 14.5. 56.8% (79) of respondents were diagnosed with disability. 46 (58.2%) of them declared moderate disability. Disability was more frequently diagnosed in patients with type 1 diabetes compared to the group of patients with type 2 diabetes (67.3% vs. 11.5%; p<0.001). Very weak correlation was found between the duration of diabetes and particular domains of the WHOQOL-Bref questionnaire (r ranging from -0.107 to -0.017; p>0.05). The subjective quality of life and the level of satisfaction with health were moderate in the group of patients with type 1 diabetes and declared disability (3.5 ± 0.9), without disability (3.4 ± 0.9) and in the group of patients with type 2 diabetes without disability (3.7 ± 0.8). The mean scores of particular domains of the WHOQOL-Bref questionnaire were very similar in patients with type 1 diabetes, both with a disability certificate (physical domain 49.0 ± 13.6; psychological domain 55.3 ± 13.7; social domain 61.1 ± 22 .8; environmental domain 54.0 ± 14.7) and without (physical domain 48.8 ± 14.0; psychological domain 55.4 ± 13.9; social domain 63.1 ± 23.3; environmental domain 55 .4 ± 14.9), and in people with type 2 diabetes (physical domain 49.8 ± 10.4; psychological domain 56.3 ± 12.1; social domain 59.8 ± 19.1; environmental domain 57, 7 ± 11.4).
Conclusions: Disability was diagnosed more often in patients with type 1 than type 2 diabetes. The disability certificate in the group of patients with type 1 diabetes does not affect the quality of life of the respondents compared to people with type 1 and type 2 diabetes without a disability certificate.
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http://dx.doi.org/10.32394/pe.77.24 | DOI Listing |
Diabetes
January 2025
Department of Geriatrics, Peking University Shenzhen Hospital, Shenzhen, China.
Insulin resistance, a hallmark of type 2 diabetes, accelerates muscle breakdown and impairs energy metabolism. However, the role of Ubiquitin Specific Peptidase 2 (USP2), a key regulator of insulin resistance, in sarcopenia remains unclear. Peroxisome proliferator activated receptor γ (PPARγ) plays a critical role in regulating muscle atrophy.
View Article and Find Full Text PDFEur Heart J
January 2025
Center for Advanced Heart and Lung Disease and Baylor Heart and Vascular Institute, Baylor University Medical Center, 3410 Worth St, Ste 250, Dallas, TX 75226, USA.
Background And Aims: Recurrent myocardial infarction (MI) and incident heart failure (HF) are major post-MI complications. Herein, contemporary post-MI risks for recurrent MI and HF are described.
Methods: A total of 6804 patients with a primary discharge diagnosis of MI at 28 Baylor Scott & White Health hospitals (January 2015 to December 2021) were studied.
J Am Soc Nephrol
January 2025
Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Background: Deficiency of adiponectin and its downstream signaling may contribute to the pathogenesis of kidney injury in type 2 diabetes. Adiponectin activates intracellular signaling via adiponectin receptors 1 and 2 (AdipoR1 and AdipoR2), but the role of AdipoR-mediated signaling in glomerular injury in type 2 diabetes remains unknown.
Methods: The expression of AdipoR1 in the kidneys of people with type 2 diabetes and the expression of podocyte proteins or injury markers in the kidneys of AdipoR1-knockout (AdipoR1-KO) mice and immortalized AdipoR1-deficient human podocytes were investigated by immunohistochemistry and immunoblotting.
Chem Biodivers
January 2025
Gannan Medical University, Depatment of Medicinal Chemistry, Gannan Medical University, 341000, Ganzhou, CHINA.
Extracting natural active ingredients from plants is an effective way to develop and screen modern drugs. Psoralea corylifolia is a leguminous plant whose seeds have long been used as a Traditional Chinese Medicine to treat psoriasis, rheumatism, dermatitis, and other diseases. To date, several main compounds, including coumarins, flavonoids, monoterpene phenols, and benzofurans, have been identified from the seeds of Psoralea corylifolia.
View Article and Find Full Text PDFDiabetes Care
January 2025
Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Objective: We investigated associations between per- and polyfluoroalkyl substances (PFAS) and changes in diabetes indicators from pregnancy to 12 years after delivery among women with a history of gestational diabetes mellitus (GDM).
Research Design And Methods: Eighty Hispanic women with GDM history were followed from the third trimester of pregnancy to 12 years after delivery. Oral and intravenous glucose tolerance tests were conducted during follow-up.
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