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The Transcription Factor SOX18 Inhibitor Small Molecule 4 Is a Potential Treatment of Cancer-Induced Lymphatic Metastasis and Lymphangiosarcoma.
Cancer Rep (Hoboken)
January 2025
Department of Plastic, Hand, and Reconstructive Microsurgery, BG Unfallklinik Frankfurt Am Main, Affiliated Hospital of Goethe-University, Frankfurt am Main, Germany.
Background: Malignant tumors release growth factors, promoting lymphangiogenesis in primary tumors and draining sentinel lymph nodes, ultimately facilitating lymph node metastasis. As a malignant lymphatic tumor entity, lymphangiosarcomas are characterized by low survival rates and limited treatment options. The transcription factor SOX18 plays a crucial role in both lymphatic endothelial cell differentiation and cancer-induced lymphangiogenesis.
View Article and Find Full Text PDFChitosan Nanoparticle-Mediated Delivery of R.Br. Root Methanolic Extract: A Promising Strategy for Breast Cancer Therapy in DMBA-Induced Breast Cancer in Sprague Dawley Rats.
Antioxidants (Basel)
December 2024
Department of Botany, Bharathiar University, Coimbatore 641046, TN, India.
R.Br., a plant native to the Western Ghats, is recognized for its diverse medicinal properties.
View Article and Find Full Text PDFKPNA2/KPNB1 promotes the malignant progression of gastric cancer induced by M2 macrophage polarization.
Tissue Cell
December 2024
Department of Oncology, Wuzhong People's Hospital Affiliated to Ningxia Medical University, China.
Macrophages in the tumor microenvironment (TME) regulated gastric cancer progression, but the mechanism of macrophage polarization in gastric cancer progression remained unclear. This study mainly explored the molecular mechanism of macrophage polarization in the tumor microenvironment and its impact on the progression of gastric cancer. KPNA2 and KPNB1 expressions in cancer tissues and adjacent non-cancerous tissues were quantified via RT-qPCR and western blot.
View Article and Find Full Text PDFAssociation between cardiometabolic index and all-cause and cause-specific mortality among the general population: NHANES 1999-2018.
Lipids Health Dis
December 2024
Department of Oncology, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, P.R. China.
Background: Cardiometabolic index (CMI) is a comprehensive clinical parameter which integrates overweight and abnormal lipid metabolism. However, its relationship with all-cause, cardiovascular disease (CVD), and cancer mortality is still obscure. Thus, a large-scale cohort study was conducted to illustrate the causal relation between CMI and CVD, cancer, and all-cause mortality among the common American population.
View Article and Find Full Text PDFCharacterization of a Cancer-Induced Bone Pain Model for Use as a Model of Cancer Cachexia.
Curr Issues Mol Biol
November 2024
Department of Pharmacology, Faculty of Pharmacy, Niigata University of Pharmacy and Medical and Life Sciences, 265-1 Higashijima, Akiha-ku, Niigata 956-8603, Japan.
Cancer cachexia is a debilitating syndrome characterized by progressive weight loss, muscle wasting, and systemic inflammation. Despite the prevalence and severe consequences of cancer cachexia, effective treatments for this syndrome remain elusive. Therefore, there is a greater need for well-characterized animal models to identify novel therapeutic targets.
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