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Metabotropic NMDA Receptor Signaling Contributes to Sex Differences in Synaptic Plasticity and Episodic Memory. | LitMetric

AI Article Synopsis

  • * The study reveals distinct roles for non-classical metabotropic NMDA receptor functions in males and females, affecting how each sex consolidates long-term memories.
  • * Blocking specific receptors impacts memory differently: while it hampers male mice's ability to form memories, it disrupts females' memory through estrogen receptor interference, highlighting crucial sex differences in memory encoding mechanisms.

Article Abstract

Men generally outperform women on encoding spatial components of episodic memory whereas the reverse holds for semantic elements. Here we show that female mice outperform males on tests for non-spatial aspects of episodic memory ("what", "when"), suggesting that the human findings are influenced by neurobiological factors common to mammals. Analysis of hippocampal synaptic plasticity mechanisms and encoding revealed unprecedented, sex-specific contributions of non-classical metabotropic NMDA receptor (NMDAR) functions. While both sexes used non-ionic NMDAR signaling to trigger actin polymerization needed to consolidate long-term potentiation (LTP), NMDAR GluN2B subunit antagonism blocked these effects in males only and had the corresponding sex-specific effect on episodic memory. Conversely, blocking estrogen receptor alpha eliminated metabotropic stabilization of LTP and episodic memory in females only. The results show that sex differences in metabotropic signaling critical for enduring synaptic plasticity in hippocampus have significant consequences for encoding episodic memories.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10849651PMC
http://dx.doi.org/10.1101/2024.01.26.577478DOI Listing

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