Phytochemical and antimicrobial properties of different plants and investigation of their bioactive compounds in wound healing and rheumatism.

In the current study the assessment of the antimicrobial and phytochemical properties of and plants extracts was carried out. The antibacterial potential of these plants extracts was tested against and . The and leaves showed the larger zone of inhibition in aqueous and butanolic extract respectively against and leaves showed larger zone of inhibition in ethanolic extract against . Qualitative phytochemical analysis showed the presence of alkaloids, flavonoids, phenols, terpenoids, steroids, glycosides, saponins, carbohydrates, proteins and tannins in all extracts while phylobatannins, emodins, anthocyanins and leucoanthocyanins were not present in these extracts. Quantitative phytochemical analysis showed the highest alkaloid content in the leaves. Highest tannin content and flavonoid content was found in leaves, while highest phenolic content was found in case of . In addition to this antioxidant potential of all the extracts was determined. leaves showed highest antioxidant potential as compared to other plant extracts. analysis of bioactive components present in plant extracts was performed by molecular docking. The rutin and Glu from and respectively, were docked with Glycogen Synthase Kinase 3 beta (1GSK-3beta) protein. Quercetin and rutin from and respectively, were docked with C- reactive protein (CRP). The tested bioactive compounds showed good binding affinity with significant number of hydrogen bonds and can be used as a good alternative of synthetic drugs to treat rheumatism and wounds.