Introduction: Hepatocellular carcinoma (HCC) has a high mortality rate, with curative resection being the primary treatment. However, HCC patients have a large possibility of recurrence within 5 years after curative resection.
Methods: Thus, identifying biomarkers to predict recurrence is crucial. In our study, we analyzed data from CCLE, GEO, and TCGA, identifying eight oncogenes associated with HCC. Subsequently, the expression of 8 genes was tested in 5 cases of tumor tissues and the adjacent non-tumor tissues. Then , and were selected to verify the expression in 63 cases of tumor tissues and the adjacent non-tumor tissues. The results showed that , were generally highly expressed in tumor tissues. A five-year follow-up of the 63 clinical cases, combined with Kaplan-Meier Plotter's relapse-free survival (RFS) analysis, found a significant correlation between expression and recurrence in HCC patients. Subsequently, we analyzed the mutations and found that the gene mutations can lead to a shorter disease-free survival time for HCC patients.
Results: The results of enrichment analysis indicated that the differentially expressed genes related to are mainly enriched in the signal release pathway.
Conclusion: In conclusion, our research showed that might be related to recurrence in HCC patients, and the expression of in tumor tissue might be a potential prognostic biomarker after tumor resection in HCC patients.
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| http://dx.doi.org/10.2174/0113892029277262231108105441 | DOI Listing |
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