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Mutant p53 Gain-of-Function in the Spotlight: Are We Suffering a GOF Delusion? | LitMetric

Mutant p53 Gain-of-Function in the Spotlight: Are We Suffering a GOF Delusion?

Cancer Discov

Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Solna, Sweden.

Published: February 2024

AI Article Synopsis

Article Abstract

Mutant p53 proteins are often highly expressed in human cancers and have been thought to have oncogenic driver gain-of-function (GOF) properties. Wang and colleagues show, surprisingly, that this is not the case because removing the TP53-mutant gene from human and mouse cancer cells using CRISPR technology has no effect on cancer cell growth in vitro or in vivo. See related article by Wang et al., p. 362 (10) .

Download full-text PDF

Source
http://dx.doi.org/10.1158/2159-8290.CD-23-1362DOI Listing

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