A nickel-catalyzed reductive -arylative cyclization of alkynyl enones with aryl halides has been developed. The reaction avoids the use of stoichiometric organometallic reagents and has a broad reaction scope and high functional group tolerance. This method offers an efficient way to access a variety of synthetically useful carbocycles that are widely found in many natural products and biologically active molecules.
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| http://dx.doi.org/10.1021/acs.joc.3c02120 | DOI Listing |
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