AI Article Synopsis
- This study explored the biocompatibility, osteogenic potential, and antibacterial properties of magnesium alloy biomedical devices created through the Superplastic Forming (SPF) process and treated with Hydrothermal (HT) and Sol-Gel methods.
- Both treatment types showed high biocompatibility, with the cellular analysis revealing increased expression of osteogenic genes and reduced bacterial growth when in contact with the magnesium-treated devices compared to controls.
- The results suggest that these modified magnesium alloys could improve temporary devices used in maxillary reconstruction, potentially reducing the need for additional surgeries and lowering the risk of implant failures from bacterial infections.
Article Abstract
Objectives: This study aimed to investigate the biocompatibility, osteogenic and antibacterial activity of biomedical devices based on Magnesium (Mg) Alloys manufactured by Superplastic Forming process (SPF) and subjected to Hydrothermal (HT) and Sol-Gel Treatment (Sol-Gel).
Methods: Mg-SPF devices subjected to Hydrothermal (Mg-SPF+HT) and Sol-Gel Treatment (Mg-SPF+Sol-Gel) were investigated. The biocompatibility of Mg-SPF+Sol-Gel and Mg-SPF+HT devices was observed by indirect and direct cytotoxicity assays, whereas the colonization of sample surfaces was assessed by confocal microscopy. qRT-PCR analysis and microbial growth curve analyses were employed to evaluate the osteogenic and antibacterial activity of both SPF-Mg treated devices, respectively.
Results: Mg-SPF+HT and Mg-SPF+Sol-Gel showed a high degree of biocompatibility. Analysis of mRNA expression of osteogenic genes in cells cultured on Mg-treated devices revealed a significant upregulation of the expression levels of BMP2 and Runx-2. Furthermore, the bacterial growth in strains developed in contact with both the Mg-SPF+HT and Mg-SPF+Sol-Gel devices was lower than that observed in the control.
Significance: Hydrothermal and Sol-Gel Treatments of Mg alloys obtained through the SPF process demonstrated bioactive, osteogenic and antibacterial activity, offering a promising alternative to conventional Mg-based devices. The obtained Mg-based materials may have the potential to enhance the tunability of temporary devices in maxillary reconstruction, eliminating the need for second surgeries, and ensuring a good bone reconstruction and a reduced implant failure rate due to bacterial infections.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.dental.2024.01.005 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Accelerating repair of infected bone defects through post-reinforced injectable hydrogel mediated antibacterial/immunoregulatory microenvironment at bone-hydrogel interface.
Carbohydr Polym
March 2025
Department of Orthopedics Trauma and Microsurgery, Zhongnan Hospital, Wuhan University, Wuhan 430000, China; Hubei Clinical Medical Research Center of Trauma and Microsurgery, Wuhan 430000, China. Electronic address:
Functional injectable hydrogel (IH) is promising for infected bone defects (IBDs) repair, but how to endow it with desired antibacterial/immunoregulatory functions as well as avoid mechanical failures during its manipulation has posed as main challenges. Herein, rosmarinic acid (RosA), a natural product with antibacterial/immunoregulatory activities, was utilized to develop a FCR IH through forming phenylboronic acid ester bonds with 4-formylphenyl phenylboronic acid (4-FPBA) grafted chitosan (CS) (FC). After being applied to the IBD site, the FCR IH was then injected with tobramycin (Tob) solution, another alkaline antibacterial drug, to induce in situ crystallization of the FC, endowing the resultant FCRT hydrogel with adaptively enhanced mechanical strength and structural stability.
View Article and Find Full Text PDFA deformable SIS/HA composite hydrogel coaxial scaffold promotes alveolar bone regeneration after tooth extraction.
Bioact Mater
April 2025
School and Hospital of Stomatology, Tianjin Medical University, Tianjin, 300070, China.
After tooth extraction, alveolar bone absorbs unevenly, leading to soft tissue collapse, which hinders full regeneration. Bone loss makes it harder to do dental implants and repairs. Inspired by the biological architecture of bone, a deformable SIS/HA (Small intestinal submucosa/Hydroxyapatite) composite hydrogel coaxial scaffold was designed to maintain bone volume in the socket.
View Article and Find Full Text PDFAdvancements in GelMA bioactive hydrogels: Strategies for infection control and bone tissue regeneration.
Theranostics
January 2025
Department of Endodontics, Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, China.
Infectious bone defects present a significant clinical challenge, characterized by infection, inflammation, and subsequent bone tissue destruction. Traditional treatments, including antibiotic therapy, surgical debridement, and bone grafting, often fail to address these defects effectively. However, recent advancements in biomaterials research have introduced innovative solutions for managing infectious bone defects.
View Article and Find Full Text PDFAscorbate-loaded MgFe layered double hydroxide for osteomyelitis treatment.
J Control Release
January 2025
Department of Traumatology and Orthopaedic Surgery, Huizhou Central People's Hospital, Huizhou 516001, China; Hui Zhou-Hong Kong Bone Health Joint Research Center, Institute of Orthopaedics, Huizhou Central People's Hospital, Huizhou 516001, China. Electronic address:
Article Synopsis
- Bacterial infections pose major challenges in orthopedic treatments, as traditional antibiotics can damage cells and lead to resistance.
- A new nanoenzyme-mimicking drug, AA@LDH, has been developed that combines magnesium iron layered double hydroxide with ascorbic acid, effectively generating reactive oxygen species to kill bacteria like S. aureus and E. coli.
- This system not only significantly reduces bacterial presence but also promotes bone healing by enhancing cell function and supporting tissue regeneration, representing a promising advancement in medical treatments.
Zinc-doped hydroxyapatite loaded chitosan gelatin nanocomposite scaffolds as a promising platform for bone regeneration.
Biomed Mater
December 2024
Department of Paper Technology, Indian Institute of Technology Roorkee, Department of Paper Technology, IIT Roorkee, Saharanpur, 247001, INDIA.
The advancement in the arena of bone tissue engineering persuades us to develop novel nanocomposite scaffolds in order to improve antibacterial, osteogenic, and angiogenic properties that show resemblance to natural bone extracellular matrix. Here, we focused on the development of novel zinc-doped hydroxyapatite (ZnHAP) nanoparticles (1, 2 and 3 wt%; size: 50-60 nm) incorporated chitosan-gelatin nanocomposite scaffold, with an interconnected porous structure. The addition of ZnHAP nanoparticles decreases the pore size (~30 µm) of the chitosan gelatin scaffold.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!