AI Article Synopsis
- * Natural compounds Pterostilbene (PTE) and 6-shogaol (6-S) have shown promise in enhancing the effectiveness of SUN in treating resistant RCC cells by triggering cell death and reducing drug resistance.
- * The study found that PTE and 6-S could disrupt specific cell signaling pathways and reduce cell invasiveness, suggesting they could be beneficial as adjunct therapies alongside SUN in RCC treatment.
Article Abstract
Sunitinib (SUN) is the first-line targeted therapeutic drug for advanced renal cell carcinoma (RCC). However, SUN resistance is frequently observed to result in tumor metastasis, with a poor survival rate. Therefore, finding an effective and safe adjuvant to reduce drug resistance is important for RCC treatment. Pterostilbene (PTE) and 6-shogaol (6-S) are natural phytochemicals found in edible sources and have potential applications against various cancers. However, the biological mechanisms of PTE and 6-S in SUN-resistant RCC are still unclear. Accordingly, this study investigated the regulatory effects of PTE and 6-S on cell survival, drug resistance, and cell invasion in 786-O and SUN-resistant 786-O (786-O ) cells, respectively. The results demonstrated that PTE and 6-S induced apoptosis in both cell lines by upregulating the Bax/Bcl-2 ratio. Additionally, PTE and 6-S increased SUN sensitivity by inhibiting the expression of the RLIP76 transport protein, reduced cell invasion and downregulated MMP expression in both 786-O and 786-O cells. Mechanistically, PTE, and 6-S significantly and dose-dependently suppressed the RLIP76-initiated Ras/ERK and Akt/mTOR pathways. In summary, PTE and 6-S induce apoptosis, enhance SUN sensitivity, and inhibit migration in both 786-O and 786-O cells. These novel findings demonstrate the potential of PTE and 6-S as target therapeutic adjuvants for RCC treatment.
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| http://dx.doi.org/10.1016/j.ejphar.2024.176393 | DOI Listing |
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Article Synopsis
- * Natural compounds Pterostilbene (PTE) and 6-shogaol (6-S) have shown promise in enhancing the effectiveness of SUN in treating resistant RCC cells by triggering cell death and reducing drug resistance.
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