AI Article Synopsis
- Ischemic stroke, a leading cause of disability and death, is influenced by complex immune processes, and this study aims to uncover the relationship between various immune cells and stroke risk.
- Researchers used Mendelian randomization to analyze genetic data and established links between immune cell characteristics (like median fluorescence intensity) and the likelihood of experiencing an ischemic stroke.
- Findings highlighted specific immune cells, particularly regulatory T-cells and certain CD39+ cells, that could potentially provide neuroprotective effects against ischemic strokes, paving the way for future therapeutic strategies focused on the immune system.
Article Abstract
Background And Purpose: Ischemic stroke, a major contributor to global disability and mortality, is underpinned by intricate pathophysiological mechanisms, notably neuroinflammation and immune cell dynamics. Prior research has identified a nuanced and often paradoxical link between immune cell phenotypes and ischemic stroke susceptibility. The aim of this study was to elucidate the potential causal links between the median fluorescence intensity (MFI) and morphological parameters (MP) of 731 immune cell types and ischemic stroke risk.
Methods: By analyzing extensive genetic datasets, we conducted comprehensive Mendelian randomization (MR) analyses to discern the genetic correlations between diverse immune cell attributes (MFI and MP) and ischemic stroke risk.
Results: Our study identified key immune cell signatures linked to ischemic stroke risk. Both B cells and T cells, among other immune cell types, have a bidirectional influence on stroke risk. Notably, the regulatory T-cell phenotype demonstrates significant neuroprotective properties, with all odds ratio (OR) values and confidence intervals (CIs) being less than 1. Furthermore, CD39 phenotype immune cells, particularly CD39+ CD8+ T cells (inverse variance weighting [IVW] OR 0.92, 95% CI 0.87-0.97; p = 0.002) and CD39+ activated CD4 regulatory T cells (IVW OR 0.93, 95% CI 0.90-0.97; p < 0.001), show notable neuroprotection against ischemic stroke.
Conclusion: This investigation provides new genetic insights into the interplay between various immune cells and ischemic stroke, underscoring the complex role of immune processes in stroke pathogenesis. These findings lay a foundation for future research, which may confirm and expand upon these links, potentially leading to innovative immune-targeted therapies for stroke prevention and management.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11236043 | PMC |
| http://dx.doi.org/10.1111/ene.16226 | DOI Listing |
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