The Structure, Biology, and Mechanical Function of Tendon/Ligament-Bone Interfaces.

Tissue Eng Part B Rev

School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.

Published: October 2024

AI Article Synopsis

  • After tendon or ligament reconstruction, the connection between hard bone and soft tissue is weaker and hard to heal properly.
  • This weak interface is prone to issues after surgery, like bone loss and instability of the graft.
  • The article explores the structure, biology, and mechanics of this interface and how factors like age and physical stress can impact it.

Article Abstract

After tendon or ligament reconstruction, the interface between the hard bone and soft connective tissue is considerably weakened and is difficult to restore through healing. The tendon/ligament-bone interface is mechanically the weakest point under tensile loading and is often the source of various postoperative complications, such as bone resorption and graft laxity. A comprehensive understanding of the macro- and microfeatures of the native tendon/ligament-bone interface would be beneficial for developing strategies for regenerating the tissue. This article discusses the structural, biological, and mechanical features of the tendon/ligament-bone interfaces and how these can be affected by aging and loading conditions.

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Source
http://dx.doi.org/10.1089/ten.TEB.2023.0295DOI Listing

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