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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10918404 | PMC |
| http://dx.doi.org/10.4274/tjh.galenos.2024.2023.0420 | DOI Listing |
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Department of Hepatobiliary Surgery, Anhui Province Key Laboratory of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China (W.H., X.G.); Cyagen Biosciences (Guangzhou) Inc. Guangzhou, Guangdong, China (K.-G.H.); Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University, Urumqi, China (M.X., Y.Y., Z.S., J.T., Z.M., S.H.); Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio (W.X.); and Lantu Biopharma, Guangzhou, China (T.G.)
Rifampicin (RFP) has demonstrated potent antibacterial effects in the treatment of pulmonary tuberculosis. However, the serious adverse effects on the liver intensively limit the clinical usage of the drug. Deacetylation greatly reduces the toxicity of RFP but also retains its curative activity.
View Article and Find Full Text PDFMetabolic profiling of Verbena bonariensis L. extract by LC/MS and evaluation of the hepatoprotective potential with isoniazid- and rifampicin-induced hepatotoxicity in rats.
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King Abdulaziz University Herbarium, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
Article Synopsis
- The study investigated the liver-protecting effects of Verbena bonariensis L. methanol extract (VBM) against liver damage caused by isoniazid and rifampicin in rats.
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Rifampicin-Induced Toxic Hepatitis in a Patient with Hemophilia After Chemical Synovectomy.
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Ege University Faculty of Medicine, Department of Pediatric Hematology, İzmir, Türkiye
Hepatoprotective effect of hydromethanol extract of benth leaves in isoniazid and rifampicin induced Swiss albino mice.
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Department of Biochemistry, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Ethiopia.
Introduction: Drug-induced liver injury is the most common cause of acute liver failure. Off-Target effect "hepatotoxicity "frequently detected during clinical examination of patients on -Tb medication particularly isoniazid (INH), and rifampin (RMP). However, there is no any treatment option against isoniazid and rifampicin induced hepatotoxicity.
View Article and Find Full Text PDFRifampicin-induced ER stress and excessive cytoplasmic vacuolization instigate hepatotoxicity via alternate programmed cell death paraptosis in vitro and in vivo.
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November 2023
Food Drug and Chemical Toxicology Group, CSIR-Indian Institute of Toxicology Research, Vishvigyan Bhawan, 31, Mahatma Gandhi Marg, Lucknow 226001, Uttar Pradesh, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India. Electronic address:
Aims: Rifampicin-induced hepatotoxicity is a primary cause of drug-induced liver injury (DILI), posing a significant challenge to its continued clinical application. Moreover, the mechanism underlying rifampicin-induced hepatotoxicity remains unclear.
Main Methods: Human hepatocyte line-17 (HHL-17) cells were treated with an increasing dose of rifampicin for 24 h, and male Wistar rats were given rifampicin [150 mg/kg body weight (bw)] orally for 28 days.
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