Objective: The aim of this study was to explore the resting-state functional connectivity (rsFC) of amygdala subregions in healthy controls (HCs) and in patients with Crohn's disease (CD) both with and without anxiety or depression.
Materials And Methods: A total of 33 patients with CD and with anxiety or depression (CDad group), 31 patients with CD but without anxiety or depression (CDnad group), and 29 age-, sex-, and education level-matched HCs underwent functional magnetic resonance imaging. rsFC analysis was used to analyze the FC between the amygdala subregions and other areas of the brain.
Results: Compared with the HC group, the CDad group demonstrated decreased rsFC between the right laterobasal subregion and the left hippocampus ( < .001) and right middle frontal gyrus ( < .001) and between the left superficial subregion and the left insula ( < .001). Compared with the HC group, the CDnad group demonstrated decreased rsFC between the left centromedial subregion and the left insula ( < .001). Compared with the CDnad group, the CDad group demonstrated decreased rsFC between the left centromedial subregion and the right precuneus ( < .001) and postcentral gyrus ( < .001), between the right laterobasal subregion and the left hippocampus ( < .001), and between the left superficial subregion and the right middle frontal gyrus ( < .001).
Conclusions: There are significant FC changes in the amygdala subregions in patients with CD. These changes may be related to the disease itself or to the symptoms of anxiety and depression.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10846920 | PMC |
| http://dx.doi.org/10.1155/2024/1551807 | DOI Listing |
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