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Theoretical study of the adsorption of analgesic environmental pollutants on pristine and nitrogen-doped graphene nanosheets.
Phys Chem Chem Phys
January 2021
Department of Chemistry and Physics, Nova Southeastern University, Fort Lauderdale, FL 33314, USA.
Interactions of the analgesic medications dextropropoxyphene (DPP, opioid), paracetamol (PCL, nonnarcotic), tramadol (TDL, nonnarcotic), ibuprofen (IBN, nonsteroidal anti-inflammatory drug (NSAID)), and naproxen (NPX, NSAID) with pristine graphene (GN) and nitrogen-doped GN (NGN; containing only graphitic N atoms) nanosheets were explored using density functional theory (DFT) in the gas and aqueous phases. Calculations in the aqueous phase were performed using the integral equation formalism polarized continuum model (IEFPCM). Calculated geometry-optimized structures, partial atomic charges (determined using Natural Bond Orbital analysis), highest occupied molecular orbital (HOMO)-lowest unoccupied molecular orbital (LUMO) energy gaps, work functions (determined using time-dependent DFT), and molecular electrostatic potential plots showed that the adsorption process is physical in nature (viz.
View Article and Find Full Text PDFAnalgesic consumption evolution at the emergency department of a university hospital (2006-2017): a defined daily doses based analysis.
Eur J Hosp Pharm
September 2020
Pharmaceutical Information Department, Centre Hospitalier Universitaire de Rennes, Rennes, France.
Objective: Pain management in the emergency department (ED) is a key issue that must be regularly evaluated. Practice evaluation gold standard remains patient file analysis, but is highly time consuming. The aim of this study is to evaluate the interest of a defined daily dose (DDD) based analysis in the evaluation of pain management in the ED.
View Article and Find Full Text PDFDextrophropoxyphene effects on QTc-interval prolongation: Frequency and characteristics in relation to plasma levels.
J Opioid Manag
March 2019
Universidad de Buenos Aires, Facultad de Medicina, Departamento de Toxicología y Farmacología, Centro de Vigilancia y Seguridad de Medicamentos e Instituto de Investigaciones Cardiológicas "Prof. Dr. Alberto C. Taquini", Buenos Aires, Argentina.
Objective: To evaluate frequency and risk factors for dextropropoxypheneinduced QT-interval prolongation in the clinical setting.
Design: Prospective, noninterventional, observational, longitudinal cohort approach. Electrocardiograms were blindly evaluated by independent professionals.
Effect of the market withdrawal of dextropropoxyphene on use of other prescribed analgesics.
Scand J Pain
October 2018
Division of Mental and Physical Health, Norwegian Institute of Public Health, Oslo, Norway.
Background and aims Dextropropoxyphene (DXP) is a synthetic opioid that was prescribed worldwide for mild to moderate pain. It was withdrawn from the European market in 2009. In this study we aim to investigate the effect of the market withdrawal of dextropropoxyphene in Norway on overall use of opioids and other analgesics at an individual level.
View Article and Find Full Text PDFThe extent and correlates of community-based pharmaceutical opioid utilisation in Australia.
Pharmacoepidemiol Drug Saf
May 2016
School of Medicine, University of Tasmania, Hobart, Tasmania, Australia.
Purpose: There has been concern regarding the increasing use of opioids and related harm. We present data on opioid utilisation across Australia and consider sociodemographic factors that may affect utilisation rates.
Methods: IMS Health national sales data for over-the-counter (codeine) and prescription opioids (buprenorphine, codeine, dextropropoxyphene, fentanyl, hydromorphone, methadone, morphine, oxycodone, tapentadol and tramadol) were used to estimate total utilisation rates in the community during 2013, mapped to Statistical Local Areas (SLAs) and Remoteness Areas.
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