Three undescribed isosteroidal alkaloids, przewalskines A-C (1-3), as well as seven known alkaloids (4-10) were obtained from Fritillaria przewalskii bulbs. Their structures were deduced by extensive HRESIMS, 1D NMR, and 2D NMR analyses, and their bioactivities were evaluated involving the anti-inflammatory and inhibitory potencies on AChE, BChE, and Aβ aggregation. Compound 4 revealed the potent effect on inhibiting Aβ aggregation activity with IC value of 33.1 μM, AChE activity with IC value of 6.9 μM, and also showed NO release inhibitory acitivity with IC value of 32.6 μM. These findings contribute new multi-.target anti-AD agents and embody the chemical diversity of F. przewalskii.
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http://dx.doi.org/10.1002/cbdv.202400017 | DOI Listing |
Chem Biodivers
March 2024
Department of Pharmacy Engineering, Tianjin University of Technology, Tianjin, 300384, People's Republic of China.
Three undescribed isosteroidal alkaloids, przewalskines A-C (1-3), as well as seven known alkaloids (4-10) were obtained from Fritillaria przewalskii bulbs. Their structures were deduced by extensive HRESIMS, 1D NMR, and 2D NMR analyses, and their bioactivities were evaluated involving the anti-inflammatory and inhibitory potencies on AChE, BChE, and Aβ aggregation. Compound 4 revealed the potent effect on inhibiting Aβ aggregation activity with IC value of 33.
View Article and Find Full Text PDFFront Chem
April 2023
Department of Pharmacy, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, China.
This paper focuses on determining the authenticity and identifying the species of using electronic nose, electronic tongue, and electronic eye sensors, near infrared and mid-level data fusion. 80 batches of and its counterfeits (including several batches of Hsiao et K.C.
View Article and Find Full Text PDFFront Microbiol
February 2023
College of Pharmacy, Gansu University of Chinese Medicine, Lanzhou, Gansu, China.
Front Plant Sci
January 2022
School of Life Sciences and Engineering, Southwest Jiaotong University, Chengdu, China.
Fritillaria species, a well-known Chinese traditional medicine for more than 2,000 years, have become rare resources due to excessive harvesting. In order to balance the economical requirement and ecological protection of species, it is necessary to determine (1) the important environmental variables that were responsible for the spatial distribution, (2) distribution change in response to climate change in the future, (3) ecological niche overlap between various species, and (4) the correlation between spatial distribution and phylogenies as well. In this study, the areas with potential ecological suitability for , , and were predicted using MaxEnt based on the current occurrence records and bioclimatic variables.
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