Image-guided radiotherapy (IGRT) systems using ionizing radiation may increase the risk of secondary cancer and normal tissue toxicity due to additional radiation exposure caused by large field sizes or repeated scans during X-ray imaging. As an alternative to these modalities, surface-guided radiotherapy (SGRT) systems which do not employ ionizing radiation have been developed. This study presents a comprehensive performance evaluation of the Varian Identify SGRT system by using an anthropomorphic Alderson Rando phantom in three different aspects: (a) the accuracy and reproducibility of the system in different regions of interest (ROI) for varying couch displacements, (b) the setup accuracy of the system for patient positioning based on different computed tomography (CT) slice thicknesses, and (c) the potential influence of obstructing SGRT cameras by the gantry on the system's overall accuracy and reproducibility. The accuracy and reproducibility of the SGRT system fell within 1 mm and 1°. Nevertheless, in certain situations, these values were observed to exceed prescribed limits. Consequently, concerning SGRT tolerance limits for treatment applications, careful consideration of ROIs and offset values of the system is crucial. We also recommend that patients should ideally be set up during 0° gantry rotation, and the on-board imaging (OBI) system should be retracted to prevent obstruction of the cameras. Additionally, reference CT images with a slice thickness of under 3 mm are recommended for this purpose.
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