Electrocardiogram (ECG) delineation to identify the fiducial points of ECG segments, plays an important role in cardiovascular diagnosis and care. Whilst deep delineation frameworks have been deployed within the literature, several factors still hinder their development: (a) data availability: the capacity of deep learning models to generalise is limited by the amount of available data; (b) morphology variations: ECG complexes vary, even within the same person, which degrades the performance of conventional deep learning models. To address these concerns, we present a large-scale 12-leads ECG dataset, ICDIRS, to train and evaluate a novel deep delineation model-ECGVEDNET. ICDIRS is a large-scale ECG dataset with 156,145 QRS onset annotations and 156,145 T peak annotations. ECGVEDNET is a novel variational encoder-decoder network designed to address morphology variations. In ECGVEDNET, we construct a well-regularized latent space, in which the latent features of ECG follow a regular distribution and present smaller morphology variations than in the raw data space. Finally, a transfer learning framework is proposed to transfer the knowledge learned on ICDIRS to smaller datasets. On ICDIRS, ECGVEDNET achieves accuracy of 86.28%/88.31% within 5/10 ms tolerance for QRS onset and accuracy of 89.94%/91.16% within 5/10 ms tolerance for T peak. On QTDB, the average time errors computed for QRS onset and T peak are -1.86 ± 8.02 ms and -0.50 ± 12.96 ms, respectively, achieving state-of-the-art performances on both large and small-scale datasets. We will release the source code and the pre-trained model on ICDIRS once accepted.
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http://dx.doi.org/10.1109/TBME.2024.3363077 | DOI Listing |
Sci Rep
January 2025
Division for Neurogeriatrics, Centre for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
Copy number variation (CNV) of the amyloid-β precursor protein gene (APP) is a known cause of autosomal dominant Alzheimer disease (ADAD), but de novo genetic variants causing ADAD are rare. We report a mother and daughter with neuropathologically confirmed definite Alzheimer disease (AD) and extensive cerebral amyloid angiopathy (CAA). Copy number analysis identified an increased number of APP copies and genome sequencing (GS) revealed the underlying complex genomic rearrangement (CGR) including a triplication of APP with two unique breakpoint junctions (BPJs).
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January 2025
Department of Experimental Biology, Genetics Area, University of Jaén, Campus Las Lagunillas s/n, 23071, Jaén, Spain.
Acanthocephalan parasites are often overlooked in many areas of research, and satellitome and cytogenetic analyzes are no exception. The species of the genus Acanthocephalus are known for their very small chromosomes with ambiguous morphology, which makes karyotyping difficult. In this study, we performed the first satellitome analysis of three Acanthocephalus species to identify species- and chromosome-specific satellites that could serve as cytogenetic markers.
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January 2025
Institute of Nature Conservation, Polish Academy of Sciences, al. Adama Mickiewicza 33, 31- 120, Kraków, Poland.
Identifying macroplastic deposition hotspots in rivers is essential for planning cleanup efforts and assessing the risks to aquatic life and the aesthetic value of river landscapes. Recent fieldwork in mountain rivers has shown that wood jams retain significantly more macroplastic than other emergent surfaces within river channels. Here, we experimentally verify these findings by tracking the deposition of 64 PET bottles after 52-65 days of transport in the mid-mountain Skawa River (Polish Carpathians) under low to medium flow conditions.
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January 2025
School of Life Sciences and Allied Health Professions, Anatomy Division, Kamuzu University of Health Sciences, Blantyre, Malawi.
Fractures of the humerus are common on the midshaft of the bone, often causing injury to the nutrient artery. Successful fracture repair and healing requires preservation of the blood supply to the long bones which is conveyed through the nutrient foramina (NF). The topography of long bone NF varies in different populations.
View Article and Find Full Text PDFZhonghua Kou Qiang Yi Xue Za Zhi
January 2025
Department of Stomatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology & School of Stomatology, Tongji Medical College, Huazhong University of Science and Technology & Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration, Wuhan 430022, China.
To investigate the effects of artificial light at night on the growth of mandibles in mice and its regulatory mechanisms. A mouse model of artificial light at night (night light pollution group) and normal lighting (normal light group) was established by controlling light exposure time, with 4 mice in each group. Micro-CT was employed to analyze the differences in bone quantities of the mandibles between the two groups.
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