Stochastic transmission in epidemiological models.

J Math Biol

Mathematics Department, Khalifa University, Abu Dhabi, 127788, UAE.

Published: February 2024

Recent empirical evidence suggests that the transmission coefficient in susceptible-exposed-infected-removed-like (SEIR-like) models evolves with time, presenting random patterns, and some stylized facts, such as mean-reversion and jumps. To address such observations we propose the use of jump-diffusion stochastic processes to parameterize the transmission coefficient in an SEIR-like model that accounts for death and time-dependent parameters. We provide a detailed theoretical analysis of the proposed model proving the existence and uniqueness of solutions as well as studying its asymptotic behavior. We also compare the proposed model with some variations possibly including jumps. The forecast performance of the considered models, using reported COVID-19 infections from New York City, is then tested in different scenarios. Despite the simplicity of the epidemiological model, by considering stochastic transmission, the forecasted scenarios were fairly accurate.

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00285-023-02042-zDOI Listing

Publication Analysis

Top Keywords

stochastic transmission
8
transmission coefficient
8
proposed model
8
transmission epidemiological
4
epidemiological models
4
models empirical
4
empirical evidence
4
evidence suggests
4
suggests transmission
4
coefficient susceptible-exposed-infected-removed-like
4

Similar Publications

Mathematical and statistical methods are invaluable in epidemiological investigations, enhancing our understanding of disease transmission dynamics and informing effective control measures. In this study, we presented a method to estimate transmissibility using patient-level data, with application to the 2015 MERS outbreak at Pyeongtaek St. Mary's Hospital, the Republic of Korea.

View Article and Find Full Text PDF

Dedicator of Cytokinesis 2 regulates cytoskeletal actin dynamics and is essential for platelet biogenesis and functions.

Cardiovasc Res

January 2025

Department of Pharmacology, School of Basic Medicine, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.

Aims: Dedicator of Cytokinesis 2 (DOCK2), a member of the DOCK family of Guanine nucleotide exchange factors that specifically act on the Rho GTPases including Rac and Cdc42, plays pivotal roles in the regulation of leukocyte homeostasis. However, its functions in platelets remain unknown.

Methods And Results: Using mice with genetic deficiency of DOCK2 (Dock2-/-), we showed that Dock2-/-mice exhibited a macrothrombocytopenic phenotype characterized as decreased platelet count and enlarged platelet size by transmission electron microscopy.

View Article and Find Full Text PDF

Background: U.S. Immigration and Customs Enforcement (ICE) facilities had high rates of COVID-19 infections and mortality during the global pandemic.

View Article and Find Full Text PDF

Amphibian decline and extinction have been observed on a global scale, highlighting the urgency of identifying the underlying factors. This issue has long been recognized as a critical concern in conservation ecology and continues to receive significant attention. Pathogen infection, in particular the chytrid fungus Batrachochytrium dendrobatidis, is postulated as a key factor contributing to the decline of certain species within specific regions.

View Article and Find Full Text PDF

Outbreak of carbapenem resistant Klebsiella pneumoniae in a neurorehabilitation unit: genomic epidemiology reveals complex transmission pattern in a tertiary care hospital.

J Glob Antimicrob Resist

January 2025

Microbiology Unit, Clinical Pathology Department, Piacenza General Hospital, Piacenza, Italy; Medicine and Surgery Department, University of Parma, Parma, Italy.

Objectives: Infections by Carbapenem-Resistant Enterobacterales in hospitals represent a severe threat but little is known on outbreaks in rehabilitation wards caused by Klebsiella pneumoniae producing Klebsiella pneumoniae Carbapenemase (KPC-Kp). We report an outbreak by KPC-Kp, in a Neurorehabilitation Unit in Italy, analysed through Whole-Genome Sequencing (WGS) for transmission routes reconstruction to improve management of KPC-Kp infections in rehabilitation units.

Methods: We investigated cases and KPC-Kp isolates collected from February to October 2022 from hospital surveillance.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!