AI Article Synopsis
- The study investigates how aging affects the immune system of elderly individuals, particularly looking at protein markers like prealbumin, transferrin, and albumin, related to immune function.
- A total of 93 participants aged 65 and older were analyzed to compare lymphocyte subsets between those with high and low serum protein levels.
- Results showed that lower serum protein levels were associated with a decrease in certain immune cells (CD4+ cells) and an increase in others (CD8 cells), indicating that these protein markers may serve as indicators of immunosenescence and that protein energy malnutrition could worsen immune decline in older males.
Article Abstract
Objective: As people get older, the innate and acquired immunity of the elderly are affected, resulting in immunosenescence. Prealbumin (PAB), transferrin (TRF), and albumin (ALB) are commonly used markers to monitor protein energy malnutrition (PEM). However, their relationship with the immune system has not been fully explored.
Methods: In our study, a total of 93 subjects (≥65 years) were recruited from Tongji Hospital between January 2015 and February 2017. According to the serum levels of these proteins (PAB, TRF, and ALB), we divided the patients into the high serum protein group and the low serum protein group. Then, we compared the percent expression of lymphocyte subsets between two groups.
Results: All the low serum protein groups (PAB, TRF, and ALB) had significant decreases in the percentage of CD4+ cells, CD3CD28 cells, CD4CD28 cells and significant increases in the percentage of CD8 cells, CD8CD28 cells. PAB, TRF, and ALB levels revealed positive correlations with CD4/CD8 ratio, proportions of CD4 cells, CD3CD28 cells, CD4CD28 cells, and negative correlation with proportions of CD8 cells, CD8CD28 cells.
Conclusions: This study suggested PAB, TRF, and ALB could be used as immunosenescence indicators. PEM might accelerate the process of immunosenescence in elderly males.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/13685538.2024.2310308 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!