AI Article Synopsis
- The study investigated how a 7-day fasting period affects oxidative stress and antioxidant defenses in different tissues of Colossoma macropomum fish.
- Fasting resulted in increased levels of oxidative stress markers (MDA and PCO) and enhanced antioxidant responses (SOD and GPX) in the liver and intestine, while other tissues like the gills and muscle showed decreased antioxidant activity.
- Findings suggest tissue-specific responses to fasting, with the liver and intestine being the most affected, and the plasma demonstrating the weakest antioxidant response.
Article Abstract
The present study was conducted to evaluate the effects of fasting on responses of oxidative biomarkers and antioxidant defenses using different organs and tissues of Colossoma macropomum. The fish were divided into two groups: fed (control) and fasting (7 days). After 7 days, the fish were sampled for assessment of oxidative stress biomarkers (MDA-lipid peroxidation and PCO-protein carbonyl) and antioxidant defenses (SOD-superoxide dismutase; CAT-catalase; GPX-glutathione peroxidase; and GST-glutathione-S -transferase) in the liver, intestine, gills, muscle, brain, and plasma. The results showed an increase in MDA, PCO, SOD, and GPX concentrations in the liver and intestine of fasting fish. In contrast, in the branchial tissue, there was a reduction in the activity of SOD and CAT enzymes in fasting fish. There was also a reduction in CAT activity in the muscle of fasting fish, while in the brain, there were no changes in oxidative stress biomarkers. Plasma showed a relatively low antioxidant response. In conclusion, our results confirm that a 7-day fasting period induced tissue-specific antioxidant responses, but the increase in antioxidant responses was only for the SOD and GPX enzymes of the liver and intestine. Additionally, the liver and intestine were the most responsive tissues, whereas the plasma was the least sensitive to oxidative stress.
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| http://dx.doi.org/10.1016/j.cbpa.2024.111595 | DOI Listing |
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