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Novel paradigm enables accurate monthly gestational screening to prevent congenital toxoplasmosis and more.
PLoS Negl Trop Dis
May 2024
Departments of Ophthalmology and Visual Science, The University of Chicago, Chicago, Illinois, United States of America.
Background: Congenital toxoplasmosis is a treatable, preventable disease, but untreated causes death, prematurity, loss of sight, cognition and motor function, and substantial costs worldwide.
Objectives: We asked whether high performance of an Immunochromatographic-test (ICT) could enable accurate, rapid diagnosis/treatment, establishing new, improved care-paradigms at point-of-care and clinical laboratory.
Methods: Data were obtained in 12 studies/analyses addressing: 1-feasibility/efficacy; 2-false-positives; 3-acceptability; 4-pink/black-line/all studies; 5-time/cost; 6-Quick-Information/Limit-of-detection; 7, 8-acute;-chronic; 9-epidemiology; 10-ADBio; 11,12-Commentary/Cases/Chronology.
Advancing multiplex serology.
Microbiol Spectr
April 2024
Division of Infections and Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Unlabelled: is a highly prevalent pathogen causing zoonotic infections with significant public health implications. Yet, our understanding of long-term consequences, associated risk factors, and the potential role of co-infections is still limited. Seroepidemiological studies are a valuable approach to address open questions and enhance our insights into across human populations.
View Article and Find Full Text PDFBackground: Congenital toxoplasmosis is a treatable, preventable disease, but untreated causes death, prematurity, loss of sight, cognition and motor function, and substantial costs worldwide.
Methods/findings: In our ongoing USA feasibility/efficacy clinical trial, data collated with other ongoing and earlier published results proved high performance of an Immunochromatographic-test(ICT) that enables accurate, rapid diagnosis/treatment, establishing new paradigms for care. Overall results from patient blood and/or serum samples tested with ICT compared with gold-standard-predicate-test results found ICT performance for 4606 sera/1876 blood, 99.
Evaluation of Seropositivity of Toxoplasmosis Suspected Patients Admitted to the National Parasitology Reference Laboratory Between 2009 and 2019.
Turkiye Parazitol Derg
August 2021
Türkiye Halk Sağlığı Kurumu, Mikrobiyoloji Referans Laboratuvarları Daire Başkanlığı Ulusal Parazitoloji Laboratuvarı, Ankara, Türkiye
Objective: Toxoplasmosis caused by , which is an obligatory intracellular parasite, is a worldwide zoonotic parasitic disease. In this study, results of test conducted between January 2009 and May 2019 were analysed. This study aimed to evaluate the results of test of patients who were admitted to the General Directorate of Public Health, National Parasitology Reference Laboratory between 2009 and 2019.
View Article and Find Full Text PDFSeroprevalence of and in Zoonotic Diseases in European Hares ().
Turkiye Parazitol Derg
August 2021
Ankara University Faculty of Veterinary Medicine, Department of Protozoology and Entomology, Ankara, Turkey
Objective: European hares () are among the most important animals that are connected with humans in many countries and natural life. Hares are important for public health, since they carry many zoonotic diseases, such as and . The study aimed to determine the seroprevalence of and and the potential zoonotic risk posed by hares that live in provinces of Turkey.
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