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Gonadal Hormone Changes with Aging and Their Impact on Chronic Pain.
Cells
January 2025
Advocate Illinois Masonic Medical Center, Department of Anesthesiology, Chicago, IL 60657, USA.
Chronic pain, pain that lasts beyond three months, is a common finding in the elderly. It is often due to musculoskeletal conditions but can be precipitated by other factors as well. While physiological systems decline with aging, chronic pain is influenced by changes in hormone profiles as men and women enter into andropause and menopause, respectively.
View Article and Find Full Text PDFDifferences/disorders of sex development (DSDs) are a diverse group of congenital conditions that result in disagreement between an individual's sex chromosomes, gonads, and/or anatomical sex. The 46, XY DSD group is vast and includes various conditions caused by genetic variants, hormonal imbalances, or abnormal sensitivity to testicular hormones, leading to varying degrees of under-virilization. A 19-year-old phenotypically normal female from Kakamega, Kenya, presented with primary amenorrhea.
View Article and Find Full Text PDF[A CASE OF TESTICULAR TUMOR UNDER CONSIDERATION FOR PARTIAL ORCHIECTOMY THROUGH RAPID INTRAOPERATIVE DIAGNOSIS].
Nihon Hinyokika Gakkai Zasshi
January 2025
Department of Urology and Renal Transplantation, Yokohama City University Medical Center.
A 35-year-old man visited a local doctor for continuing analysis of his infertility. Semen analysis revealed azoospermia while an ultrasonography detected a right testicular tumor with a diameter of 10 mm. A blood test was negative for tumor markers.
View Article and Find Full Text PDFCommunity pharmacy's role in dispensing androgens and supporting harm reduction amid current policy dilemmas.
Subst Abuse Treat Prev Policy
January 2025
Griffith Centre for Mental Health, Griffith University, Brisbane, QLD, Australia.
Background: Legitimate androgen use, such as testosterone replacement therapy, requires a legal prescription. Off-label use for reasons like wellness and aesthetics continues to grow. Recent regulatory changes in Australia aim to curb non-prescribed androgen use, potentially intensifying stigma, however seeking prescriptions through legal channels persists.
View Article and Find Full Text PDFClinician's guide to the management of azoospermia induced by exogenous testosterone or anabolic-androgenic steroids.
Asian J Androl
January 2025
Global Andrology Forum, 130 West Juniper Lane, Moreland Hills, OH 44022, USA.
Azoospermia, defined as the absence of sperm in the ejaculate, is a well-documented consequence of exogenous testosterone (ET) and anabolic-androgenic steroid (AAS) use. These agents suppress the hypothalamic-pituitary-gonadal (HPG) axis, leading to reduced intratesticular testosterone levels and impaired spermatogenesis. This review examines the pathophysiological mechanisms underlying azoospermia and outlines therapeutic strategies for recovery.
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