As one of the most intriguing nanozymes, the platinum (Pt) nanozyme has attracted tremendous research interest due to its various catalytic activities but its application is still limited by its poor colloidal stability and low affinity to substrates. Here, we design a highly stable Pt@carbon dot (Pt@CD) hybrid nanozyme with enhanced peroxidase (POD)-like activity (specific activity of 1877 U mg). The Pt@CDs catalyze the decomposition of hydrogen peroxide (HO) to produce singlet oxygen and hydroxyl radicals and exhibit high affinity to HO and high specificity to 3,3',5,5'-tetramethyl-benzidine. We reveal that both the hydroxyl and carbonyl groups of CDs could coordinate with Pt and then regulate the charge state of the Pt nanozyme, facilitating the formation of Pt@CDs and improving the POD-like activity of Pt@CDs. Colorimetric detection assays based on Pt@CDs for HO, dopamine, and glucose with a satisfactory detection performance are achieved. Moreover, the Pt@CDs show a HO-involving antibacterial effect by destroying the cell membrane. Our findings provide new opportunities for designing hybrid nanozymes with desirable stability and catalytic performance by using CDs as nucleating templates and stabilizers.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1039/d3nr04964g | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Iron/phosphorus co-doped carbon nanozyme for colorimetric sensing of organophosphorus pesticides in food.
Anal Methods
January 2025
Chongqing Key Laboratory of New Energy Storage Materials and Devices, School of Science, Chongqing University of Technology, Chongqing 400054, P. R. China.
In this work, a peroxidase-like (POD-like) nanozyme of Fe/P-NC was synthesized by doping phosphorus (P) and nitrogen (N) to manipulate iron (Fe) activity centers, which showed catalytic activity and kinetics comparable to those of natural HRP. Based on the efficient POD-like activity of the Fe/P-NC nanozyme and cascaded catalytic reactions with acetylcholinesterase (AChE), we constructed a colorimetric, affordable and sensitive sensing platform to detect organophosphorus pesticides (OPs). In the presence of AChE, the POD-like activity of the prepared Fe/P-NC was suppressed, which weakened the Fe/P-NC-catalyzed oxidation of TMB.
View Article and Find Full Text PDFCeFe nanofibrous carbon nanozyme integrated with smartphone for the point-of-care testing of norfloxacin in water.
J Pharm Anal
October 2024
School of Chemistry and Chemical Engineering, Nanchang University, Nanchang, 330031, China.
The overuse of antibiotics has led to the severe contamination of water bodies, posing a considerable hazard to human health. Therefore, the development of an accurate and rapid point-of-care testing (POCT) platform for the quantitative detection of antibiotics is necessary. In this study, Cerium oxide (CeO) and Ferrosoferric oxide (FeO) nanoparticles were simultaneously encapsulated into N-doped nanofibrous carbon microspheres to form of a novel nanozyme (CeFe-NCMzyme) with a porous structure, high surface area, and N-doped carbon material properties, leading to a considerable enhancement of the peroxidase (POD)-like activity compared with that of the CeO or FeO nanoparticles alone.
View Article and Find Full Text PDFPdRu bimetallic nanoalloys with improved photothermal effect for amplified ROS-mediated tumor therapy.
Front Bioeng Biotechnol
January 2025
Department of Experimental Research and Guangxi Cancer Molecular Medicine Engineering Research Center and Guangxi Key Laboratory of Basic and Translational Research for Colorectal Cancer, Guangxi Medical University Cancer Hospital, Nanning, China.
An emerging strategy in cancer therapy involves inducing reactive oxygen species (ROS), specifically within tumors using nanozymes. However, existing nanozymes suffer from limitations such as low reactivity, poor biocompatibility, and limited targeting capabilities, hindering their therapeutic efficacy. In response, the PdRu@PEI bimetallic nanoalloys were constructed with well-catalytic activities and effective separation of charges, which can catalyze hydrogen peroxide (HO) to toxic hydroxyl radical (·OH) under near-infrared laser stimulation.
View Article and Find Full Text PDFSingle-Atom Iridium-doped Carbon Dots Nanozyme with High Peroxidase-Like Activity as Colorimetric Sensors for Multimodal Detection of Mercury Ions.
Small
January 2025
Chongqing Key Laboratory of Prevention and Treatment for Occupational Diseases and Poisoning, First Affiliated Hospital of Chongqing Medical and Pharmaceutical College, Chongqing, 400060, China.
Nanozyme-based colorimetric sensors are promising approaches for environmental monitoring, food safety, and medical diagnostics. However, developing novel nanozymes that exhibit high catalytic activity, good dispersion in aqueous solution, high sensitivity, selectivity, and stability is challenging. In this study, for the first time, single-atom iridium-doped carbon dot nanozymes (SA Ir-CDs) are synthesized via a simple in situ pyrolysis process.
View Article and Find Full Text PDFElectronic structure modulation of ultrathin PtRuMoCoNi high-entropy alloy nanowires for boosting peroxidase-like activity and sensitive colorimetric determination of isoniazid and hydrazine.
Mikrochim Acta
January 2025
Department of General Surgery, Hui Ya Hospital of The First Affiliated Hospital, Sun Yat-Sen University, Huizhou, 516081, Guangdong, China.
Self-supported ultrathin PtRuMoCoNi high-entropy alloy nanowires (HEANWs) were synthesized by a one-pot co-reduction method, whose peroxidase (POD)-like activity and catalytic mechanism were elaborated in detail. As expected, the PtRuMoCoNi HEANWs showed excellent POD-like activity. It can quickly catalyze the oxidization of colorless 3,3',5,5'-tetramethylbenzidine (TMB) to blue TMB through decomposition of HO to superoxide radicals.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!